Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Ann Thorac Surg. 2020 Jan;109(1):148-153. doi: 10.1016/j.athoracsur.2019.06.042. Epub 2019 Aug 7.
The purpose of this study was to assess the outcomes of slide tracheoplasty and tracheal resection in pediatric patients and analyze the data for predictors of outcomes.
A retrospective review of tracheal surgery from January 1, 1993 to May 1, 2018 was performed. Demographic data, operative details, perioperative data, and clinical outcomes were collected. The study investigators' management strategy has evolved over time, with less rigid bronchoscopy, more reliance on postoperative computed tomographic imaging, and the use of inhaled Ciprodex (combination of ciprofloxacin and dexamethasone) since 2007.
The study included 41 patients, with a median age of 4.1 months and a median weight of 4.2 kg. There were 6 neonates and 24 infants. Slide tracheoplasty was performed in 27 patients (66%), and resection with end-to-end anastomosis was performed in 14 (34%). Eleven patients (27%) had a pulmonary artery sling. Simultaneous intracardiac repairs requiring cross-clamp and cardioplegia were performed in 9 patients (22%). Lung agenesis (n = 6) or severe hypoplasia (n = 2) was present in 8 patients (20%). Complications included tracheostomy in 5 patients (12%) and in-hospital death in 3 patients (7%). There were no cases of mediastinitis. Inhaled Ciprodex was used to decrease granulation tissue at suture lines. Median intubation time was 7 days, and median length of stay was 25.0 days. There was no difference in outcomes when comparing intracardiac repairs with the remaining patients, lung agenesis or hypoplasia vs the remaining cohort, or neonates vs infants.
Slide tracheoplasty and tracheal resection are effective operative strategies for infants and children with tracheal stenosis, including patients with lung agenesis/hypoplasia. Simultaneous repair of intracardiac anomalies and pulmonary artery sling is recommended.
本研究旨在评估小儿滑式气管成形术和气管切除术的治疗效果,并分析预测治疗效果的因素。
回顾性分析 1993 年 1 月 1 日至 2018 年 5 月 1 日期间的气管手术。收集人口统计学数据、手术细节、围手术期数据和临床结果。研究人员的治疗策略随时间演变,自 2007 年以来,支气管镜检查更灵活,更依赖术后 CT 成像,且使用吸入性 Ciprodex(环丙沙星和地塞米松的组合)。
本研究共纳入 41 例患儿,中位年龄 4.1 个月,体重 4.2kg。其中 6 例为新生儿,24 例为婴儿。27 例行滑式气管成形术(66%),14 例行气管切除术端端吻合术(34%)。11 例(27%)存在肺动脉吊带。9 例(22%)患儿同时存在需要体外循环和心脏停搏的心脏内畸形。8 例(20%)存在肺不发育(n=6)或严重发育不良(n=2)。5 例(12%)患儿需要行气管切开术,3 例(7%)患儿院内死亡。无纵隔炎病例。使用吸入性 Ciprodex 减少缝线处肉芽组织。中位气管插管时间为 7 天,中位住院时间为 25.0 天。心脏内畸形修复与其他患者、肺不发育/发育不良与其他患儿或新生儿与婴儿之间的治疗效果无差异。
滑式气管成形术和气管切除术是治疗小儿气管狭窄的有效手术策略,包括肺不发育/发育不良患儿。建议同期修复心脏内畸形和肺动脉吊带。