Cai Qiuyi, Wen Bing, Li Jianlin, Hu Liangbo, Liu Jian, Yang Hao
Department of Radiology, The Third People's Hospital of Chengdu, Chengdu, China.
Department of Radiology, Yiyang Central Hospital, Yiyang, China.
Transl Pediatr. 2022 Apr;11(4):565-574. doi: 10.21037/tp-22-87.
Pulmonary artery sling (PAS) is associated with tracheal stenosis and left pulmonary artery (LPA) dysplasia in infants, both developmental abnormalities that may lead to pulmonary hypoplasia and lung volume changes. As such, we aimed to monitor the effects of tracheal stenosis and pulmonary vascular malformation on lung volumes in infants with PAS and their correlation with lung volumes in infants with PAS using dual-source computed tomography (DSCT).
A case-control study was performed. From May 2009 to June 2017, we retrospectively enrolled patients with surgically confirmed PAS and compared them to matched normal controls (A healthy control group comprising age- and gender-matched patients with adequate imaging data was used for the comparisons.). All the patients underwent DSCT examinations. We measured and compared the diameters of the trachea, main bronchus, and main pulmonary artery (MPA) and its branches, and both lung volumes on the axial, and reconstructed CT images.
There were no statistical differences in the diameters of the MPA or right pulmonary artery (RPA) between patients (N=15) and controls (N=28). The diameter of the main bronchus, the bilateral trachea and the left pulmonary artery were all smaller in the PAS group than in the control group, and significant differences were evident in the left lung volume the right lung volume, and the right-to-left lung volume ratio between the 2 groups. Pearson's correlation and linear regression analyses between the diameters of the trachea and MPA, total lung volume, ipsilateral bronchial and pulmonary artery branches, and ipsilateral lung volume ranged from 0.71 to 0.87 and 0.57 to 0.77 for the control and PAS groups, respectively.
Tracheal stenosis and LPA dysplasia in infants with PAS cause alterations in lung tissue morphology and physiological development, resulting in reduced bilateral lung volumes.
肺动脉吊带（PAS）与婴儿气管狭窄和左肺动脉（LPA）发育异常相关，这两种发育异常都可能导致肺发育不全和肺容积变化。因此，我们旨在使用双源计算机断层扫描（DSCT）监测气管狭窄和肺血管畸形对PAS婴儿肺容积的影响及其与PAS婴儿肺容积的相关性。
进行了一项病例对照研究。2009年5月至2017年6月，我们回顾性纳入了手术确诊为PAS的患者，并将他们与匹配的正常对照进行比较（使用一个由年龄和性别匹配且有足够影像学数据的健康对照组进行比较）。所有患者均接受了DSCT检查。我们在轴位和重建的CT图像上测量并比较了气管、主支气管、主肺动脉（MPA）及其分支的直径以及双肺容积。
患者组（N = 15）和对照组（N = 28）之间MPA或右肺动脉（RPA）的直径无统计学差异。PAS组的主支气管、双侧气管和左肺动脉的直径均小于对照组，两组之间左肺容积、右肺容积以及右肺与左肺容积比存在显著差异。对照组和PAS组中，气管和MPA直径、总肺容积、同侧支气管和肺动脉分支以及同侧肺容积之间的Pearson相关性和线性回归分析范围分别为0.71至0.87和0.57至0.77。
PAS婴儿的气管狭窄和LPA发育异常导致肺组织形态和生理发育改变，导致双侧肺容积减小。
