Department of Medical Nanotechenology, School of Medicine, Shahroud University of Medical Science, Shahroud, Iran; Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran; Tissue Engeenering and Stem Cells Research Center, School of Medicine, Shahroud University of Medical Science, Shahroud, Iran.
Colloids Surf B Biointerfaces. 2019 Nov 1;183:110407. doi: 10.1016/j.colsurfb.2019.110407. Epub 2019 Jul 30.
Recently developed methodologies related to surface modification of nanoparticles provide nano systems with the final properties required for a desired application. In nano-pharmaceutical field, the major goals of surface modification are to make nanoparticles unrecognizable by the immune system and to guide them to the desired site. Such a modification can be accomplished through functionalization of NPs by conjugating or coating a molecule whose properties alter nanoparticle surface characteristics. In his regard, gelatin-based nanoparticles (GNPs) have shown great potential as multifunctional drug delivery systems because they could be easily tailored by including targeting moieties, hydrophilic polymers, fluorescence dyes, or different therapeutic agents without the loss of their desired physical, chemical, and biological properties. Research on GNPs for drug and gene delivery has been increasing dramatically over the last decade due to their special features such as good biocompatibility, biodegradability, and low immunogenicity. This review provides an overview of the ongoing research in the field of recent advances in the functionalization of gelatin based NPs for pharmaceutical and medical applications.
最近开发的与纳米粒子表面改性相关的方法为纳米系统提供了所需应用所需的最终特性。在纳米制药领域，表面改性的主要目标是使纳米粒子不被免疫系统识别，并将其引导至所需的部位。这种改性可以通过将具有改变纳米粒子表面特性的性质的分子与 NPs 缀合或涂层来完成。在这方面，基于明胶的纳米粒子 (GNPs) 作为多功能药物递送系统显示出巨大的潜力，因为它们可以通过包括靶向部分、亲水性聚合物、荧光染料或不同的治疗剂来轻松定制，而不会失去所需的物理、化学和生物特性。由于其良好的生物相容性、生物降解性和低免疫原性等特殊性质，过去十年中，GNPs 在药物和基因递送方面的研究急剧增加。本综述概述了最近在基于明胶的 NPs 功能化方面的研究进展，这些进展可用于制药和医疗应用。
