dos Santos Marlise A, Grenha Ana
Joan-Vernikos Aerospace Pharmacy Laboratory, School of Pharmacy, Microgravity Centre, Pontifical Catholic University of Rio Grande do Sul PUCRS, Porto Alegre, Brazil.
CBME-Centre for Molecular and Structural Biomedicine/IBB-Institute for Biotechnology and Bioengineering, Faculty of Sciences and Technology, University of Algarve, Campus de Gambelas, Faro, Portugal.
Adv Protein Chem Struct Biol. 2015;98:223-61. doi: 10.1016/bs.apcsb.2014.11.003. Epub 2015 Mar 3.
Finding adequate carriers for protein and peptide delivery has become an urgent need, owing to the growing number of macromolecules identified as having therapeutic potential. Nanoparticles have emerged in the field as very promising vehicles and much work has been directed to testing the capacity of different materials to compose the matrix of these carriers. Natural materials and, specifically, polysaccharides have been taking the forefront of the challenge, because of several favoring properties that include the higher propensity to exhibit biodegradability and biocompatibility, and also the high structural flexibility. The majority of works found in the literature regarding polysaccharide nanoparticles uses very popular materials like chitosan or hyaluronic acid. This review is aimed at describing and exploring the potential of polysaccharides that are not so well known or that are less explored. For those, the main properties will be described, together with an overview of the reported applications as nanoparticle matrix materials.
由于被鉴定具有治疗潜力的大分子数量不断增加，寻找合适的蛋白质和肽递送载体已成为当务之急。纳米颗粒已作为非常有前景的载体出现在该领域，并且已经开展了大量工作来测试不同材料构成这些载体基质的能力。天然材料，特别是多糖，由于具有一些有利特性，包括更高的生物降解性和生物相容性倾向以及高结构灵活性，已处于挑战的前沿。文献中关于多糖纳米颗粒的大多数研究使用的是壳聚糖或透明质酸等非常常见的材料。本综述旨在描述和探索那些不太知名或研究较少的多糖的潜力。对于这些多糖，将描述其主要特性，并概述其作为纳米颗粒基质材料的报道应用。
