Elzoghby Ahmed O, Elgohary Mayada M, Kamel Nayra M
Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Adv Protein Chem Struct Biol. 2015;98:169-221. doi: 10.1016/bs.apcsb.2014.12.002. Epub 2015 Mar 12.
Protein-based nanocarriers have gained considerable attention as colloidal carrier systems for the delivery of anticancer drugs. Protein nanocarriers possess various advantages including their low cytotoxicity, abundant renewable sources, high drug-binding capacity, and significant uptake into the targeted tumor cells. Moreover, the unique protein structure offers the possibility of site-specific drug conjugation and tumor targeting using various ligands modifying the surface of protein nanocarriers. In this chapter, we highlight the most important applications of protein nanoparticles (NPs) for the delivery of anticancer drugs. We examine the various techniques that have been utilized for the preparation of anticancer drug-loaded protein NPs. Finally, the current chapter also reviews the major outcomes of the in vitro and in vivo investigations of surface-modified tumor-targeted protein NPs.
基于蛋白质的纳米载体作为抗癌药物递送的胶体载体系统已受到广泛关注。蛋白质纳米载体具有多种优势，包括低细胞毒性、丰富的可再生来源、高药物结合能力以及对靶向肿瘤细胞的显著摄取。此外，独特的蛋白质结构使得通过修饰蛋白质纳米载体表面的各种配体实现位点特异性药物偶联和肿瘤靶向成为可能。在本章中，我们重点介绍蛋白质纳米颗粒（NPs）在抗癌药物递送方面的最重要应用。我们研究了用于制备负载抗癌药物的蛋白质 NPs 的各种技术。最后，本章还综述了表面修饰的肿瘤靶向蛋白质 NPs 的体外和体内研究的主要成果。
