Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
J Affect Disord. 2019 Oct 1;257:765-773. doi: 10.1016/j.jad.2019.07.037. Epub 2019 Jul 6.
We studied 48 MDD and 30 HC who performed an emotional conflict task in a functional magnetic resonance imaging (fMRI) scanner.
On the emotional conflict task, MDD and HC demonstrated a robust emotional Stroop effect in reaction time and accuracy. Overall, accuracy was lower in MDD compared to HC with no significant reaction time differences. The fMRI data indicated lower BOLD activation in MDD compared to HC on comparisons of all trials, congruent, incongruent, and incongruent > congruent trials in regions including right inferior temporal gyrus, lateral occipital cortex, and occipital fusiform gyrus. Behavioural and neuroimaging data indicated no group differences in fearful versus happy face processing.
Inclusion of a neutral condition may have provided a valuable contrast to how MDD and HC process stimuli without emotional valence compared to stimuli with a strong emotional valence.
MDD and HC demonstrated a robust emotional Stroop effect. Compared to HC, MDD demonstrated an overall reduced accuracy on the emotional conflict task and reduced BOLD activity in regions important for face perception and emotion information processing, with no differences in responding to fearful versus happy faces. These findings provide support for the theory of emotion context insensitivity in individuals with depression.
我们研究了 48 名 MDD 和 30 名 HC，他们在功能磁共振成像（fMRI）扫描仪上执行情感冲突任务。
在情感冲突任务中，MDD 和 HC 在反应时间和准确性方面表现出强烈的情绪 Stroop 效应。总体而言，MDD 的准确性低于 HC，而反应时间没有显著差异。与 HC 相比，MDD 在所有试验、一致试验、不一致试验和不一致>一致试验的比较中，右颞下回、外侧枕叶皮质和枕叶梭状回的大脑血氧水平依赖（BOLD）激活较低。行为和神经影像学数据表明，MDD 和 HC 在处理恐惧面孔与快乐面孔时没有差异。
纳入中性条件可能会提供有价值的对比，即 MDD 和 HC 如何在没有情绪效价的情况下处理刺激，而不是具有强烈情绪效价的刺激。
MDD 和 HC 表现出强烈的情绪 Stroop 效应。与 HC 相比，MDD 在情感冲突任务中的整体准确性较低，在对面孔感知和情绪信息处理重要区域的大脑 BOLD 活动较低，而对恐惧面孔和快乐面孔的反应没有差异。这些发现为抑郁个体的情绪情境不敏感理论提供了支持。
