Berenfeld Omer, Efimov Igor
Department of Internal Medicine (Cardiology), Center for Arrhythmia Research, University of Michigan, 7300 Medical Science Building, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
Department of Biomedical Engineering, The George Washington University, 800 22nd Street Northwest, 5000 Science and Engineering Hall, Washington, DC 20052, USA.
Card Electrophysiol Clin. 2019 Sep;11(3):495-510. doi: 10.1016/j.ccep.2019.04.004.
Optical mapping of electrical activity in the heart is based on voltage-sensitive and lipophilic fluorescence dyes. Optical signals recorded from cardiac cells correlate well with their transmembrane potentials. High spatiotemporal resolution, wide field mapping, and high sensitivity to transmembrane potential enable detailed characterization of action potential initiation and propagation. Optical mapping is used to study complex patterns of excitation propagation, including propagation across the sinoatrial and atrioventricular nodes and during atrial and ventricular arrhythmias.Optical mapping is used to study the role of reentrant activity in atrial and ventricular fibrillation.
心脏电活动的光学映射基于电压敏感和亲脂性荧光染料。从心脏细胞记录的光学信号与其跨膜电位密切相关。高时空分辨率、宽视野映射以及对跨膜电位的高灵敏度能够详细表征动作电位的起始和传播。光学映射用于研究兴奋传播的复杂模式，包括跨窦房结和房室结的传播以及心房和心室心律失常期间的传播。光学映射用于研究折返活动在心房和心室颤动中的作用。
