Kholmovski Eugene G, Morris Alan K, Chelu Mihail G
Comprehensive Arrhythmia Research & Management (CARMA) Center, University of Utah, 729 Arapeen Drive, Salt Lake City, Ut 84108, USA; Utah Center for Advanced Imaging Research (UCAIR), University of Utah, Salt Lake City, UT, USA; Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Comprehensive Arrhythmia Research & Management (CARMA) Center, University of Utah, 729 Arapeen Drive, Salt Lake City, Ut 84108, USA.
Card Electrophysiol Clin. 2019 Sep;11(3):537-549. doi: 10.1016/j.ccep.2019.04.005.
Left atrial fibrosis plays an important role in the pathophysiology of atrial fibrillation. Left atrial ablation is an effective and increasingly used strategy to restore and maintain sinus rhythm in patients with atrial fibrillation. Late gadolinium enhancement (LGE) MRI and custom image analysis software have been used to visualize and quantify preablation atrial fibrosis and postablation scar and new fibrosis formation. This article reviews technical aspects of imaging atrial fibrosis/scar by LGE-MRI; use of atrial fibrosis and scar in predicting outcomes; applications of LGE-MRI to assess ablation lesions and optimize ablation parameters while avoiding collateral damage.
左心房纤维化在心房颤动的病理生理学中起重要作用。左心房消融是恢复和维持心房颤动患者窦性心律的一种有效且应用日益广泛的策略。延迟钆增强（LGE）磁共振成像（MRI）和定制图像分析软件已被用于可视化和量化消融前的心房纤维化、消融后的瘢痕以及新的纤维化形成。本文综述了通过LGE-MRI对心房纤维化/瘢痕进行成像的技术方面；心房纤维化和瘢痕在预测预后中的应用；LGE-MRI在评估消融损伤和优化消融参数同时避免附带损伤方面的应用。
