The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
J Cell Mol Med. 2021 Mar;25(6):2764-2775. doi: 10.1111/jcmm.16350. Epub 2021 Feb 11.
Atrial fibrillation (AF), the commonest arrhythmia, shows associations with various disease conditions. Mounting evidence indicates that atrial fibrosis is an important part of the arrhythmogenic substrate, with an essential function in the generation of conduction abnormalities that underlie the transition from paroxysmal to persistent AF, which in turn contributes to AF perpetuation. Left atrial (LA) fibrosis is considered a possible major factor and predictor in AF treatment. The present review provides insights into LA fibrosis' association with AF. The information is focused on clinical aspects and mechanisms, clinical evaluating methods that evaluate fibrosis changes and examining possible options for the prevention of atrial fibrosis.
心房颤动（AF）是最常见的心律失常，与多种疾病状况有关。越来越多的证据表明，心房纤维化是心律失常基质的重要组成部分，在产生传导异常方面具有重要作用，这些异常是阵发性向持续性 AF 转变的基础，进而促进 AF 的持续。左心房（LA）纤维化被认为是 AF 治疗中的一个重要因素和预测因子。本综述提供了关于 LA 纤维化与 AF 相关性的深入了解。信息集中在临床方面和机制、评估纤维化变化的临床评估方法以及探讨预防心房纤维化的可能选择。
