School of Nursing, University of California, San Francisco, CA, United States of America.
School of Medicine, University of California, San Francisco, CA, United States of America.
J Neuroimmunol. 2019 Oct 15;335:577019. doi: 10.1016/j.jneuroim.2019.577019. Epub 2019 Aug 2.
Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for neuroinflammatory (NI) related signaling pathways and whole-transcriptome profiles from other experiments. Pathway impact analysis identified 8 perturbed NI related pathways. Expression profile analysis found 15 experiments having similar whole-transcriptome profiles of DGE related to neuroinflammation and PIPN. These findings suggest that perturbations in pathways associated with neuroinflammation are found in cancer survivors with PIPN.
紫杉醇是一种常见的化疗药物，与慢性紫杉醇诱导的周围神经病变（PIPN）的发展有关。在临床前研究中，PIPN 与神经炎症机制有关。在这里，我们评估了患有和不患有 PIPN 的乳腺癌幸存者外周血中的差异基因表达（DGE），以及其他实验中的神经炎症（NI）相关信号通路和全转录组谱。途径影响分析确定了 8 个受干扰的与 NI 相关的途径。表达谱分析发现，有 15 个实验具有与神经炎症和 PIPN 相关的 DGE 的相似全转录组谱。这些发现表明，患有 PIPN 的癌症幸存者中存在与神经炎症相关的途径扰动。
