阿尔茨海默病患者面部表情识别的电生理证据：一项综合 ERP 研究。
Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study.
机构信息
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychology, Dokuz Eylul University, Izmir, Turkey; Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
出版信息
Clin Neurophysiol. 2019 Oct;130(10):1813-1824. doi: 10.1016/j.clinph.2019.06.229. Epub 2019 Jul 12.
OBJECTIVES
The present study aims to evaluate the amplitude and latency of event-related potentials (ERPs) P100, N170, VPP and N230 in individuals with Alzheimer's disease (AD) compared to healthy elderly controls, using a passive viewing task of emotional facial expressions.
METHODS
Twenty-four individuals with mild to moderate AD and 23 demographically matched healthy elderly controls were included in the study. ERP P100, N170, VPP and N230 amplitude and latency values were compared between groups.
RESULTS
The categorization of emotional facial expressions was intact; yet, increased P100 amplitude and latency, decreased N170 amplitude, and increased VPP amplitude were observed in AD compared to controls. Increased N230 amplitude and latency were observed in response to angry expressions, while neutral expressions elicited decreased amplitude and latency.
CONCLUSIONS
Increased P100 amplitude and latency may reflect reduced amygdala volume and disruptions in the visual system, while decreased N170 and increased VPP amplitudes may reflect impaired perceptual processing, mitigated by a greater involvement of prefrontal areas for task performance in AD.
SIGNIFICANCE
This study is the first to report a complex pattern of ERPs to emotional facial expressions in individuals with AD.
目的
本研究旨在通过情绪面部表情的被动观察任务，评估阿尔茨海默病（AD）患者与健康老年对照组个体的事件相关电位（ERPs）P100、N170、VPP 和 N230 的振幅和潜伏期。
方法
本研究纳入了 24 名轻度至中度 AD 患者和 23 名年龄匹配的健康老年对照组个体。比较了两组个体的 ERP P100、N170、VPP 和 N230 振幅和潜伏期值。
结果
AD 患者的情绪面部表情分类完整，但与对照组相比，P100 振幅和潜伏期增加，N170 振幅降低，VPP 振幅增加。愤怒表情引起 N230 振幅和潜伏期增加，而中性表情则引起振幅和潜伏期降低。
结论
P100 振幅和潜伏期的增加可能反映了杏仁核体积的减少和视觉系统的紊乱，而 N170 的降低和 VPP 的增加可能反映了感知加工受损，这可能是由于 AD 患者为完成任务而更大程度地涉及额前区。
意义
本研究首次报道了 AD 患者对情绪面部表情的复杂 ERP 模式。
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