University of Pittsburgh, Department of Psychiatry, Loeffler Building, Room 304, 121 Meyran Ave, Pittsburgh, PA 15213, USA.
University of Pittsburgh, Department of Psychiatry, Loeffler Building, Room 304, 121 Meyran Ave, Pittsburgh, PA 15213, USA.
J Affect Disord. 2019 Nov 1;258:125-132. doi: 10.1016/j.jad.2019.07.066. Epub 2019 Jul 30.
Drifts between wakefulness and sleep are common during resting state functional MRI (rsfMRI). Among healthy adults, within-scanner sleep can impact functional connectivity of default mode (DMN), task-positive (TPN), and thalamo-cortical networks. Because dysfunctional arousal states (i.e., sleepiness, sleep disturbance) are common in affective disorders, individuals with affective psychopathology may be more prone to unstable wakefulness during rsfMRI, hampering the estimation of clinically meaningful functional connectivity biomarkers.
A transdiagnostic sample of 150 young adults (68 psychologically distressed; 82 psychiatrically healthy) completed rsfMRI and reported whether they experienced within-scanner sleep. Symptom scales were reduced into depression/anxiety and mania proneness dimensions using principal component analysis. We evaluated associations between within-scanner sleep, clinical status, and functional connectivity of the DMN, TPN, and thalamus.
Within-scanner sleep during rsfMRI was reported by 44% of participants (n = 66) but was unrelated to psychiatric diagnoses or mood symptom severity (p-values > 0.05). Across all participants, self-reported within-scanner sleep was associated with connectivity signatures akin to objectively-assessed sleep, including lower within-DMN connectivity, lower DMN-TPN anti-correlation, and altered thalamo-cortical connectivity (p < 0.05, corrected). Among participants reporting sustained wakefulness (n = 84), depression/anxiety severity positively associated with averaged DMN-TPN connectivity and mania proneness negatively associated with averaged thalamus-DMN connectivity (p-values < 0.05). Both relationships were attenuated and became non-significant when participants reporting within-scanner sleep were included (p-values > 0.05).
Subjective report of within-scanner sleep.
Findings implicate within-scanner sleep as a source of variance in network connectivity; careful monitoring and correction for within-scanner sleep may enhance our ability to characterize network signatures underlying affective psychopathology.
在静息态功能磁共振成像（rsfMRI）中，清醒和睡眠之间的漂移很常见。在健康成年人中，扫描内睡眠会影响默认模式（DMN）、任务正激活（TPN）和丘脑-皮质网络的功能连接。由于情感障碍中常见的功能障碍性觉醒状态（即嗜睡、睡眠障碍），患有情感精神病理学的个体在 rsfMRI 期间可能更容易出现不稳定的觉醒，从而阻碍了对临床有意义的功能连接生物标志物的估计。
一个跨诊断的 150 名年轻成年人样本（68 名心理困扰；82 名心理健康）完成了 rsfMRI，并报告他们是否在扫描内经历了睡眠。使用主成分分析将症状量表简化为抑郁/焦虑和躁狂倾向维度。我们评估了扫描内睡眠、临床状况以及 DMN、TPN 和丘脑的功能连接之间的关联。
44%的参与者（n=66）报告在 rsfMRI 扫描期间出现了扫描内睡眠，但与精神诊断或情绪症状严重程度无关（p 值>0.05）。在所有参与者中，自我报告的扫描内睡眠与类似于客观评估睡眠的连接特征相关，包括 DMN 内连接降低、DMN-TPN 负相关降低以及丘脑-皮质连接改变（p<0.05，校正）。在报告持续清醒的参与者中（n=84），抑郁/焦虑严重程度与平均 DMN-TPN 连接呈正相关，躁狂倾向与平均丘脑-DMN 连接呈负相关（p 值<0.05）。当包括报告扫描内睡眠的参与者时，这两种关系都减弱且变得不显著（p 值>0.05）。
扫描内睡眠的主观报告。
研究结果表明，扫描内睡眠是网络连接中变异性的一个来源；仔细监测和校正扫描内睡眠可能会增强我们描述情感精神病理学潜在网络特征的能力。
