一名被诊断为胰腺高血糖素瘤的患者使用生长抑素类似物后坏死性游走性红斑消退。
Resolution of necrolytic migratory erythema with somatostatin analogue in a patient diagnosed with pancreatic glucagonoma.
作者信息
Saavedra Cristina, Lamarca Angela, Hubner Richard A
机构信息
Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
Medical Oncology, Hospital Universitario Ramon y Cajal, Madrid, Spain.
出版信息
BMJ Case Rep. 2019 Aug 10;12(8):e229115. doi: 10.1136/bcr-2018-229115.
Abstract
A 70-year-old man reported progressive weight loss, fatigue and a generalised rash. The rash was consistent with necrolytic migratory erythema, further investigations were performed and the patient was diagnosed with a mass in the tail of the pancreas, in keeping with a localised glucagonoma. Somatostatin analogue therapy was started for symptom control, leading to complete resolution of the skin rash and an improvement in constitutional symptoms. Subsequently, the pancreatic lesion was excised, and pathology assessment confirmed the diagnosis of well-differentiated neuroendocrine tumour with high expression of glucagon compatible with glucagonoma.
摘要
一名70岁男性报告有进行性体重减轻、疲劳和全身性皮疹。该皮疹与坏死性游走性红斑相符，进一步检查后，患者被诊断为胰尾有一肿块，符合局限性胰高血糖素瘤。开始使用生长抑素类似物治疗以控制症状，皮疹完全消退，全身症状有所改善。随后，切除了胰腺病变，病理评估证实诊断为高分化神经内分泌肿瘤，胰高血糖素高表达，符合胰高血糖素瘤。
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