Department of Surgical Gastroenterology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.
Pancreatology. 2013 May-Jun;13(3):327-9. doi: 10.1016/j.pan.2012.11.308. Epub 2012 Nov 23.
Glucagonoma is an uncommon type of pancreatic neuroendocrine tumor [NET] which is characterized by diabetes mellitus, necrolytic migratory erythema, depression and deep vein thrombosis. The typical rash is often misdiagnosed and the diagnosis is delayed by 7-8 years. Pancreatic NETs and other pancreatic tumors are known to show calcifications within the tumor but calcification of the remaining normal pancreas is very uncommon. It occurs when there is ductal obstruction leading to acute or chronic pancreatitis.
We present a case of glucagonoma with coexistent pancreatic calcification.
Glucagonoma should be suspected in a diabetic patient with migratory rash. Pancreatic tumor should be suspected in patient with idiopathic focal pancreatitis.
胰高血糖素瘤是一种罕见的胰腺神经内分泌肿瘤 [NET]，其特征是糖尿病、坏死性游走性红斑、抑郁和深静脉血栓形成。典型皮疹常被误诊，诊断延迟 7-8 年。胰腺 NET 和其他胰腺肿瘤已知在肿瘤内出现钙化，但剩余正常胰腺的钙化非常罕见。当发生导管阻塞导致急性或慢性胰腺炎时，就会发生这种情况。
我们报告了一例伴有胰钙化的胰高血糖素瘤病例。
对于有游走性皮疹的糖尿病患者，应怀疑胰高血糖素瘤。对于特发性局灶性胰腺炎患者，应怀疑胰腺肿瘤。
