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急性病房内联合同科多学科康复治疗能否改善重症监护幸存者的结局?一项试点随机对照试验。

Can in-reach multidisciplinary rehabilitation in the acute ward improve outcomes for critical care survivors? A pilot randomized controlled trial.

出版信息

J Rehabil Med. 2019 Sep 3;51(8):598-606. doi: 10.2340/16501977-2579.

Abstract

OBJECTIVES

To assess the feasibility of in-reach rehabilitation for critical care survivors following discharge from the intensive care unit. To determine whether additional in-reach rehabilitation reduces hospital length-of-stay and improves outcomes in critical care survivors, compared with usual therapy.

PARTICIPANTS

A total of 66 consecutively-admitted critical care survivors with an intensive care unit stay ≥ 5 days were enrolled in the study. Of these, 62 were included in the analyses.

METHODS

Pilot randomized control trial with blinded assessment at 6 and 12 months. The intervention group (n = 29) received in-reach rehabilitation in addition to usual ward therapy. The usual-care group (n = 33) received usual ward therapy. The primary outcome assessed was length-of-stay. Secondary outcomes included mobility, functional independence, psychological status and quality-of-life.

RESULTS

The intervention group received more physiotherapy and occupational therapy sessions per week than the usual-care group (median = 8.2 vs 4.9, p < 0.001). Total length-of-stay was variable; while median values differed between the intervention and usual care groups (median 31 vs 41 days), this was not significant and the pilot study was not adequately powered (p = 0.57). No significant differences were observed in the secondary outcomes at hospital discharge, 6- or 12-month follow-ups.

CONCLUSION

Provision of intensive early rehabilitation to intensive care unit survivors on the acute ward is feasible. A further trial is needed to draw conclusions on how this intervention affects length-of-stay and functional outcomes.

摘要

目的

评估从重症监护病房出院后对重症监护幸存者进行院内康复的可行性。确定与常规治疗相比,额外的院内康复是否可以减少重症监护幸存者的住院时间并改善其预后。

参与者

共纳入 66 例连续入住重症监护病房且 ICU 住院时间≥5 天的重症监护幸存者。其中 62 例纳入分析。

方法

前瞻性随机对照试验,在 6 个月和 12 个月时进行盲法评估。干预组(n=29)在常规病房治疗的基础上接受院内康复治疗。常规治疗组(n=33)接受常规病房治疗。主要结局评估为住院时间。次要结局包括移动能力、功能独立性、心理状态和生活质量。

结果

干预组每周接受的物理治疗和职业治疗次数多于常规治疗组(中位数分别为 8.2 次和 4.9 次,p<0.001)。总住院时间不同;虽然干预组和常规组的中位数有差异(中位数分别为 31 天和 41 天),但差异无统计学意义,且该初步研究的效能不足(p=0.57)。在出院时、6 个月和 12 个月的随访时,次要结局均无显著差异。

结论

在急性病房为重症监护病房幸存者提供强化早期康复是可行的。需要进一步的试验来确定这种干预措施如何影响住院时间和功能结局。

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