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高迁移率族蛋白 B1/PTEN/β-连环蛋白轴在脂多糖诱导的急性肺损伤中对调节性 T 细胞的调控作用。

The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury.

机构信息

Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

出版信息

Front Immunol. 2019 Jul 25;10:1612. doi: 10.3389/fimmu.2019.01612. eCollection 2019.

DOI:10.3389/fimmu.2019.01612
PMID:31402909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6669370/
Abstract

Sepsis-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) remains the leading complication for mortality caused by bacterial infection. The regulatory T (Treg) cells appear to be an important modulator in resolving lung injury. Despite the extensive studies, little is known about the role of macrophage HMGB1/PTEN/β-catenin signaling in Treg development during ALI. This study was designed to determine the roles and molecular mechanisms of HMGB1/PTEN/β-catenin signaling in mediating CD4CD25Foxp3 Treg development in sepsis-induced lung injury in mice. University laboratory research of First Affiliated Hospital of Anhui Medical University. PTEN/β-catenin Loxp and myeloid-specific knockout mice. Groups of PTEN/β-catenin and myeloid-specific PTEN/β-catenin knockout (PTEN/β-catenin) mice were treated with LPS or recombinant HMGB1 (rHMGB1) to induce ALI. The effects of HMGB1-PTEN axis were further analyzed by co-cultures. In a mouse model of ALI, blocking HMGB1 or myeloid-specific PTEN knockout (PTEN) increased animal survival/body weight, reduced lung damage, increased TGF-β production, inhibited the expression of RORγt and IL-17, while promoting β-catenin signaling and increasing CD4CD25Foxp3 Tregs in LPS- or rHMGB-induced lung injury. Notably, myeloid-specific β-catenin ablation (β-catenin) resulted in reduced animal survival and increased lung injury, accompanied by reduced CD4CD25Foxp3 Tregs in rHMGB-induced ALI. Furthermore, disruption of macrophage HMGB1/PTEN or activation of β-catenin significantly increased CD4CD25Foxp3 Tregs . HMGB1/PTEN/β-catenin signaling is a novel pathway that regulates Treg development and provides a potential therapeutic target in sepsis-induced lung injury.

摘要

脓毒症诱导的急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）仍然是细菌感染导致死亡的主要并发症。调节性 T（Treg）细胞似乎是解决肺损伤的重要调节剂。尽管进行了广泛的研究，但对于 HMGB1/PTEN/β-连环蛋白信号在 ALI 中调节 Treg 发育的作用知之甚少。本研究旨在确定 HMGB1/PTEN/β-连环蛋白信号在介导脓毒症诱导的肺损伤中 CD4CD25Foxp3 Treg 发育中的作用和分子机制。安徽医科大学第一附属医院大学实验室研究。PTEN/β-连环蛋白 Loxp 和髓系特异性敲除小鼠。PTEN/β-连环蛋白和髓系特异性 PTEN/β-连环蛋白敲除（PTEN/β-连环蛋白）小鼠组用 LPS 或重组 HMGB1（rHMGB1）处理以诱导 ALI。通过共培养进一步分析 HMGB1-PTEN 轴的作用。在 ALI 小鼠模型中，阻断 HMGB1 或髓系特异性 PTEN 敲除（PTEN）增加了动物的存活率/体重，减轻了肺损伤，增加了 TGF-β 的产生，抑制了 RORγt 和 IL-17 的表达，同时促进了β-连环蛋白信号传导，并增加了 LPS 或 rHMGB1 诱导的肺损伤中的 CD4CD25Foxp3 Treg。值得注意的是，髓系特异性β-连环蛋白消融（β-catenin）导致动物存活率降低和肺损伤增加，同时 rHMGB1 诱导的 ALI 中 CD4CD25Foxp3 Treg 减少。此外，巨噬细胞 HMGB1/PTEN 的破坏或β-连环蛋白的激活显着增加了 CD4CD25Foxp3 Treg。HMGB1/PTEN/β-连环蛋白信号是调节 Treg 发育的新途径，为脓毒症诱导的肺损伤提供了潜在的治疗靶点。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa06/6669370/95a911018276/fimmu-10-01612-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa06/6669370/5d60fd986806/fimmu-10-01612-g0006.jpg
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本文引用的文献

1
Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment.急性呼吸窘迫综合征：诊断与治疗的进展。
JAMA. 2018 Feb 20;319(7):698-710. doi: 10.1001/jama.2017.21907.
2
Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury.磷酸酶与张力蛋白同源物-β-连环蛋白信号通路调节小鼠肝脏缺血/再灌注损伤中的调节性T细胞和炎症反应。
Liver Transpl. 2017 Jun;23(6):813-825. doi: 10.1002/lt.24735.
3
PTEN-Foxo1 signaling triggers HMGB1-mediated innate immune responses in acute lung injury.
SNHG12下调通过调节多囊卵巢综合征中颗粒细胞的糖酵解诱导卵泡发育异常。
Front Cell Dev Biol. 2025 May 23;13:1585987. doi: 10.3389/fcell.2025.1585987. eCollection 2025.
4
Progress in cytokine research for ARDS: A comprehensive review.急性呼吸窘迫综合征细胞因子研究进展：综述
Open Med (Wars). 2024 Oct 28;19(1):20241076. doi: 10.1515/med-2024-1076. eCollection 2024.
5
The Complex Immune Cell Composition and Cellular Interaction in the Alveolar Compartment of Patients with Acute Respiratory Distress Syndrome.急性呼吸窘迫综合征患者肺泡腔中复杂的免疫细胞组成及细胞间相互作用
Am J Respir Cell Mol Biol. 2025 Mar;72(3):233-243. doi: 10.1165/rcmb.2024-0176TR.
6
Identification of qualitative characteristics of immunosuppression in sepsis based on immune-related genes and immune infiltration features.基于免疫相关基因和免疫浸润特征鉴定脓毒症中免疫抑制的定性特征
Heliyon. 2024 Apr 3;10(8):e29007. doi: 10.1016/j.heliyon.2024.e29007. eCollection 2024 Apr 30.
7
Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis.辅助性 T 细胞 17（Th17）/调节性 T 细胞（Treg）平衡：脓毒症病理生理学中的兴衰。
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9
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Int J Mol Med. 2023 Nov;52(5). doi: 10.3892/ijmm.2023.5307. Epub 2023 Sep 29.
10
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Front Pharmacol. 2023 May 24;14:1200058. doi: 10.3389/fphar.2023.1200058. eCollection 2023.
PTEN-Foxo1信号通路触发急性肺损伤中HMGB1介导的先天性免疫反应。
Immunol Res. 2015 May;62(1):95-105. doi: 10.1007/s12026-015-8639-z.
4
β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.β-连环蛋白调控的髓样细胞黏附和迁移决定伤口愈合。
J Clin Invest. 2014 Jun;124(6):2599-610. doi: 10.1172/JCI62059. Epub 2014 May 16.
5
T-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary disease.调节性T细胞和程序性死亡1阳性T细胞导致慢性阻塞性肺疾病患者效应T细胞功能障碍。
Am J Respir Crit Care Med. 2014 Jul 1;190(1):40-50. doi: 10.1164/rccm.201312-2293OC.
6
Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation.髓系细胞 PTEN 缺失通过促进 M2 巨噬细胞分化来保护肝脏免受缺血再灌注损伤。
J Immunol. 2014 Jun 1;192(11):5343-5353. doi: 10.4049/jimmunol.1400280. Epub 2014 Apr 25.
7
Alveolar macrophage phagocytic activity is enhanced with LPS priming, and combined stimulation of LPS and lipoteichoic acid synergistically induce pro-inflammatory cytokines in pigs.肺泡巨噬细胞的吞噬活性在 LPS 引发下增强，LPS 和脂磷壁酸的联合刺激在猪中协同诱导促炎细胞因子。
Innate Immun. 2013 Dec;19(6):631-43. doi: 10.1177/1753425913477166. Epub 2013 Apr 22.
8
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance.肺组织驻留的组织巨噬细胞可产生 Foxp3+调节性 T 细胞并促进气道耐受。
J Exp Med. 2013 Apr 8;210(4):775-88. doi: 10.1084/jem.20121849. Epub 2013 Apr 1.
9
High-mobility group box family of proteins: ligand and sensor for innate immunity.高迁移率族蛋白家族：天然免疫的配体和感受器。
Trends Immunol. 2012 Dec;33(12):633-40. doi: 10.1016/j.it.2012.10.005. Epub 2012 Oct 29.
10
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.PI(3)K 的 p110δ 同工型控制 TLR4 信号的亚细胞区室化，并防止内毒素休克。
Nat Immunol. 2012 Nov;13(11):1045-1054. doi: 10.1038/ni.2426. Epub 2012 Sep 30.