Yetimakman Ayse Filiz, Kesici Selman, Tanyildiz Murat, Bayrakci Benan
Division of Pediatric Intensive Care, Department of Pediatrics, Hacettepe University, Ankara, Turkey.
Department of Pediatrics, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara, Turkey.
J Pediatr Intensive Care. 2019 Sep;8(3):164-169. doi: 10.1055/s-0039-1683991. Epub 2019 Mar 27.
Severe metabolic crises in children with inborn errors of metabolism can result in mortality or severe morbidities where continuous renal replacement therapy (CRRT) can be lifesaving Clinical data, the pediatric risk of mortality (PRISM) scores calculated in the first 24 hours, and pediatric logistic organ dysfunction (PELOD) scores calculated in the last 24 hours before CRRT, were studied Overall, CRRT was successful in restoring metabolic balance in 72% of patients. PELOD scores before CRRT were lower in survivors ( = 0.02). Despite numerous comorbid factors, CRRT can be used effectively in management of metabolic crises. Early intervention with this therapy before occurrence of complications must be targeted.
患有先天性代谢缺陷的儿童发生严重代谢危机可导致死亡或严重疾病，而持续肾脏替代疗法（CRRT）可能挽救生命。研究了临床数据、CRRT前24小时计算的儿科死亡风险（PRISM）评分以及CRRT前最后24小时计算的儿科逻辑器官功能障碍（PELOD）评分。总体而言，CRRT在72%的患者中成功恢复了代谢平衡。CRRT前幸存者的PELOD评分较低（P = 0.02）。尽管存在众多合并因素，但CRRT可有效用于代谢危机的管理。必须针对并发症发生前的这种疗法进行早期干预。
