Department of Infectious Diseases, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Front Immunol. 2019 Jul 24;10:1751. doi: 10.3389/fimmu.2019.01751. eCollection 2019.
The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses.
E3 泛素连接酶的膜相关环指（MARCH）蛋白已成为免疫反应的关键调节因子。MARCH 蛋白通过不同途径将免疫受体、病毒蛋白以及先天免疫反应中的成分作为靶标进行多泛素化和降解。本文总结了 MARCH 蛋白及其对免疫反应调节的最新进展。
