Dept of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Dept of Biochemistry, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Neurochem Int. 2019 Dec;131:104509. doi: 10.1016/j.neuint.2019.104509. Epub 2019 Aug 9.
and purpose: Neuron specific enolase (NSE) is an established biomarker of neuronal damage. It is not clear how much seizures contribute to the neuronal damage, morbidity or mortality in critically ill neurology patients. The aim of this study is to determine the impact of seizures on neuronal injury in critically ill neurology patients by using neuron specific enolase as a biomarker.
Forty patients with clinical evidence of acute central nervous system disease associated with seizures were included as critically ill neurology patients with seizures [CINPS] (age in years 38.8 ± 17.54, mean ± SD; 22 males) and 43 age and sex-matched acute central nervous system disease without seizures were recruited as critically ill neurology patients [CINP] (age in years 37.84 ± 17.38 years mean ± SD; 24 males) The serum NSE assays were performed in CINPS (within 24 h of last seizure) and in CINP using an enzyme immunoassay kit.
The level of serum neuron specific enolase was significantly higher in CINP with seizures compared to those without seizures. The length of ICU stay was more prolonged in those with seizures. There was a close correlation between the NSE levels and frequency of seizures. There was no significant difference in the mortality between both the groups.
NSE a marker of neuronal injury was elevated in patients with acute central nervous system diseases. It is significantly higher in patients with seizures in comparison to those without seizures. This warrants further studies to document aggressive treatment of seizures in acute neurologically ill patients can reduce neuronal damage.
神经元特异性烯醇化酶（NSE）是神经元损伤的既定生物标志物。目前尚不清楚癫痫发作对危重病神经科患者的神经元损伤、发病率或死亡率有多大影响。本研究旨在通过使用神经元特异性烯醇化酶作为生物标志物来确定癫痫发作对危重病神经科患者神经元损伤的影响。
纳入 40 例有临床证据的急性中枢神经系统疾病合并癫痫发作的患者作为伴有癫痫发作的危重病神经科患者 [CINPS]（年龄为 38.8±17.54 岁，均值±标准差；22 名男性），并招募 43 例年龄和性别匹配的无癫痫发作的急性中枢神经系统疾病患者作为危重病神经科患者 [CINP]（年龄为 37.84±17.38 岁，均值±标准差；24 名男性）。使用酶免疫测定试剂盒在 CINPS（最后一次癫痫发作后 24 小时内）和 CINP 中进行血清 NSE 检测。
伴有癫痫发作的 CINP 患者的血清神经元特异性烯醇化酶水平明显高于无癫痫发作的患者。伴有癫痫发作的患者 ICU 住院时间延长。NSE 水平与癫痫发作频率密切相关。两组死亡率无显著差异。
神经元损伤标志物 NSE 在急性中枢神经系统疾病患者中升高。与无癫痫发作的患者相比，伴有癫痫发作的患者 NSE 水平明显升高。这需要进一步的研究来证明积极治疗急性神经疾病患者的癫痫发作可以减少神经元损伤。
