Kılıç Hüseyin, Yılmaz Kübra, Uyur Yalçın Emek, Kucur Mine, Saltık Sema
Department of Pediatric Neurology, İstanbul University-Cerrahpaşa, Cerrahpaşa Medical School, İstanbul, Turkey.
Department of Pediatric Neurology, University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, İstanbul, Turkey.
Turk Arch Pediatr. 2022 Nov;57(6):611-615. doi: 10.5152/TurkArchPediatr.2022.22151.
Neuron-specific enolase is an established biomarker of neuronal damage. This study aimed to reveal the relationship between serum neuron-specific enolase level and continuous interictal discharges in a group of encephalopathy with electrical status epilepticus in sleep patients for the first time and determine whether there is a neuronal cell loss or damage.
We analyzed serum neuron-specific enolase levels in patients with an electrical status epilepticus in sleep pattern on their electroencephalographs with age- and sex-matched control subjects. Patients with a spike-wave index of at least 50% and acquired neuropsychological regression were included in the study. Magnetic resonance imaging of all electrical status epilepticus in sleep patients and control subjects included in the study was within normal limits. Neuron-specific enolase is measured by the enzyme-linked immunosorbent assay kit based on the sandwich technique.
In this study, 14 patients diagnosed with electrical status epilepticus in sleep and 21 healthy controls were included. The median age of electrical status epilepticus in sleep patients was 7.1 years (min-max: 4.5-10.7 years) and 7.7 years (min-max: 3.2-14 years) in the control subjects. According to the results of serum neuron-specific enolase measurements, the mean ± standard deviation level of neuron-specific enolase was 7.61 ± 3.19 ng/dL for the electrical status epilepticus in sleep group and 6.93 ± 2.55 ng/dL for the control group. Serum neuron-specific enolase levels between electrical status epilepticus in sleep patients and the control group were not statistically significant (P = .749).
No significant difference was observed in serum neuron-specific enolase levels between electrical status epilepticus in sleep patients and control subjects. Our results may indicate that frequent interictal discharges do not result in neuronal cell loss or damage in electrical status epilepticus in sleep patients.
神经元特异性烯醇化酶是一种已确定的神经元损伤生物标志物。本研究旨在首次揭示一组睡眠中癫痫性电持续状态患者血清神经元特异性烯醇化酶水平与发作间期持续放电之间的关系，并确定是否存在神经元细胞丢失或损伤。
我们分析了脑电图显示为睡眠中癫痫性电持续状态模式的患者以及年龄和性别匹配的对照受试者的血清神经元特异性烯醇化酶水平。纳入研究的患者其棘波指数至少为50%且伴有获得性神经心理衰退。本研究纳入的所有睡眠中癫痫性电持续状态患者和对照受试者的磁共振成像均在正常范围内。神经元特异性烯醇化酶采用基于夹心技术的酶联免疫吸附测定试剂盒进行测量。
本研究纳入了14例诊断为睡眠中癫痫性电持续状态的患者和21例健康对照。睡眠中癫痫性电持续状态患者的中位年龄为7.1岁（最小值 - 最大值：4.5 - 10.7岁），对照受试者为7.7岁（最小值 - 最大值：3.2 - 14岁）。根据血清神经元特异性烯醇化酶测量结果，睡眠中癫痫性电持续状态组的神经元特异性烯醇化酶平均±标准差水平为7.61±3.19 ng/dL，对照组为6.93±2.55 ng/dL。睡眠中癫痫性电持续状态患者与对照组之间的血清神经元特异性烯醇化酶水平无统计学意义（P = 0.749）。
睡眠中癫痫性电持续状态患者与对照受试者之间的血清神经元特异性烯醇化酶水平未观察到显著差异。我们的结果可能表明，频繁的发作间期放电不会导致睡眠中癫痫性电持续状态患者的神经元细胞丢失或损伤。
