Lascelles B D X, Barratt D, Basran P S, Brown D C, Coetzee J F, Gill M, Hutchinson M R, Johnson C, Luna S P L, Mohapatra D P, Oshinsky M L, Robertson S, Ruberman C F, Smith E R, Zhang Q
Translational Research in Pain and Comparative Pain Research and Education Center, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.
Thurston Arthritis Center, UNC School of Medicine, Chapel Hill, NC, United States.
Front Pain Res (Lausanne). 2025 Aug 21;6:1615862. doi: 10.3389/fpain.2025.1615862. eCollection 2025.
Annually, millions of humans and animals suffer from chronic and acute pain, creating welfare and quality of life concerns for both humans and animals who suffer this pain. In developing new therapeutic approaches, the challenge is to accurately measure this pain to ascertain the efficacy of novel therapeutics. Additionally, there is a need to develop new and effective analgesic options that may offer alternatives to using opioids that contribute to the opioid epidemic. The Pain in Animals Workshop (PAW) meetings are held every other year in partnership with the National Institutes of Health (NIH), bringing key stakeholders together to understand pain in humans and animals better. The 2023 workshop focused on presenting and discussing updates on validated approaches to measuring pain, highlighting opportunity areas for additional outcome measure development. It also discussed study design and analytic approaches to the use of outcome measures in clinical trials, including the important concepts of success-failure approaches and the application of multiple endpoints in evaluating analgesic therapies. The workshop also introduced the concept of the biopsychosocial model of pain, broadening the conversation around the impact of pain and thus opportunities to modulate the pain experience. The application of artificial intelligence to the measurement of pain was introduced. The workshop brought together academia, government, and industry experts in human and animal pain assessment and analgesic intervention development. Given the topic's importance and the meeting's uniqueness, capturing the thoughts and ideas presented and discussed is critical. This narrative is one product from that meeting, summarizing several presentations from the workshop.
每年，数以百万计的人类和动物遭受着慢性和急性疼痛的折磨，这给遭受这种疼痛的人类和动物的福利及生活质量都带来了问题。在开发新的治疗方法时，挑战在于准确测量这种疼痛，以确定新型疗法的疗效。此外，还需要开发新的有效镇痛选择，以提供替代使用导致阿片类药物泛滥的阿片类药物的方法。动物疼痛研讨会（PAW）会议每隔一年与美国国立卫生研究院（NIH）合作举办一次，将关键利益相关者聚集在一起，以更好地了解人类和动物的疼痛。2023年的研讨会重点介绍和讨论了测量疼痛的有效方法的最新进展，突出了额外结局指标开发的机会领域。它还讨论了在临床试验中使用结局指标的研究设计和分析方法，包括成败方法的重要概念以及在评估镇痛疗法中应用多个终点。研讨会还介绍了疼痛的生物心理社会模型的概念，拓宽了围绕疼痛影响的讨论范围，从而也增加了调节疼痛体验的机会。会上还介绍了人工智能在疼痛测量中的应用。该研讨会汇聚了人类和动物疼痛评估及镇痛干预开发领域的学术界、政府和行业专家。鉴于该主题的重要性和会议的独特性，记录会上提出和讨论的想法和观点至关重要。这篇叙述文章就是那次会议的一个成果，总结了研讨会上的几个演讲内容。
