Byrd S E, Bohan T P, Osborn R E, Naidich T P
Department of Radiology, Northwestern University Medical School, Children's Memorial Hospital, Chicago, IL 60614.
AJNR Am J Neuroradiol. 1988 Sep;9(5):923-7.
Lissencephaly is a rare congenital malformation of the brain that has characteristic radiographic and clinical findings. Fifteen cases of lissencephaly were studied with CT and/or MR, and a classification was developed based on these cases and the description of this abnormality found in the literature. These findings can be divided into two groups, primary and secondary. The primary findings consist of (1) a cerebral surface that is agyric or agyric with pachygyric areas, (2) a cerebral contour that is oval or "hourglass" due to lack of or incomplete opercularization of the brain, and (3) an abnormal gray-white-matter distribution in the cerebral hemispheres. The primary findings are necessary to make the diagnosis, which can be made with either CT or MR; however, MR provided better delineation than CT of the cerebral surface and contour as well as better gray-white-matter differentiation in the lissencephalic brains. We believe MR is the technique of choice for evaluating patients with lissencephaly because it is safer and more versatile than CT and provides better delineation of the brains of children.
无脑回畸形是一种罕见的先天性脑畸形，具有特征性的影像学和临床发现。对15例无脑回畸形患者进行了CT和/或磁共振成像（MR）研究，并根据这些病例以及文献中对该异常的描述制定了一种分类方法。这些发现可分为两组，即原发性和继发性。原发性发现包括：（1）脑表面平滑或有巨脑回区域的平滑脑；（2）由于脑盖缺乏或不完全形成，脑轮廓呈椭圆形或“沙漏形”；（3）大脑半球内异常的灰白质分布。原发性发现是做出诊断所必需的，CT或MR均可做出诊断；然而，对于无脑回畸形的大脑，MR在显示脑表面和轮廓以及灰白质区分方面比CT更好。我们认为MR是评估无脑回畸形患者的首选技术，因为它比CT更安全、用途更广，并且能更好地显示儿童的大脑。
