Radoń-Pokracka Małgorzata, Adrianowicz Beata, Płonka Magdalena, Danił Paulina, Nowak Magdalena, Huras Hubert
Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Kraków, Poland.
Open Access Maced J Med Sci. 2019 Jun 30;7(12):1951-1956. doi: 10.3889/oamjms.2019.587.
The study aimed to investigate the association between advanced maternal age (AMA) and the risk of adverse maternal, perinatal and neonatal outcomes about parity in singleton pregnancies.
We retrospectively analysed 950 women who gave birth in the Department of Obstetrics and Perinatology of the University Hospital in Kraków for six months (between 1 January and 30 June 2018). The patients were divided into 3 groups according to their age (30-34 years old, 35-39 years old and over 40 years old). Each of these groups was subsequently subdivided into 2 groups depending on parity (primiparae and multiparae). Maternal, perinatal and neonatal outcomes were compared between the groups and the subgroups.
Comparison of the three age groups revealed that advanced maternal age might constitute a predisposing factor for preterm birth, caesarean section and large for gestational age (LGA). From these parameters, statistical significance was reached in case of greater risk of LGA (OR = 2.17), caesarean section (OR = 2.03) and elective C-section (OR = 1.84) in women over 40 years old when compared to the patients aged 30-34. Furthermore, AMA increases the risk of postpartum haemorrhage (OR = 6.43). Additionally, there is a negative correlation between maternal age and gestational age at delivery (R = -0.106, p < 0.05).
Advanced maternal age can undoubtedly be associated with several adverse perinatal outcomes. At the same time, the risk of perinatal complications begins to increase after the age of 35 but becomes significant in women aged ≥ 40.
本研究旨在探讨高龄产妇（AMA）与单胎妊娠中不同产次的孕产妇、围产期及新生儿不良结局风险之间的关联。
我们回顾性分析了950名在克拉科夫大学医院妇产科分娩的女性，研究时间为六个月（2018年1月1日至6月30日）。根据年龄将患者分为3组（30 - 34岁、35 - 39岁和40岁以上）。随后，每组又根据产次分为2组（初产妇和经产妇）。对各组及亚组的孕产妇、围产期和新生儿结局进行比较。
对三个年龄组的比较显示，高龄产妇可能是早产、剖宫产和大于胎龄儿（LGA）的易感因素。在这些参数中，与30 - 34岁的患者相比，40岁以上女性发生LGA（OR = 2.17）、剖宫产（OR = 2.03）和择期剖宫产（OR = 1.84）风险更高，差异具有统计学意义。此外，高龄产妇增加了产后出血的风险（OR = 6.43）。另外，产妇年龄与分娩时的孕周之间存在负相关（R = -0.106，p < 0.05）。
高龄产妇无疑与多种不良围产期结局相关。同时，围产期并发症的风险在35岁后开始增加，但在≥40岁的女性中变得显著。
