Phillips G, Mitchell L B, Pizzo S V
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Am J Hematol. 1988 Sep;29(1):52-3. doi: 10.1002/ajh.2830290113.
Recent studies suggest that intravascular coagulation occurs in sickle cell anemia. There is also some evidence that decreased fibrinolytic activity may be associated with the disorder. In the current study we measured tissue plasminogen activator levels (t-PA) in seven asymptomatic patients with sickle cell anemia. The mean level of releasable t-PA was only 0.01 IU/mL +/- 0.005 (SEM) as compared to 118 healthy volunteers with levels of 0.70 +/- 0.10 (SEM). Despite the small sample size, the difference between the two groups was statistically significant (P less than .001). These data suggest that defective release of t-PA may contribute to a hypercoagulable state in sickle cell anemia.
近期研究表明，血管内凝血发生于镰状细胞贫血患者。也有一些证据表明，纤溶活性降低可能与该疾病有关。在本研究中，我们检测了7例无症状镰状细胞贫血患者的组织型纤溶酶原激活物（t-PA）水平。可释放t-PA的平均水平仅为0.01 IU/mL±0.005（标准误），而118名健康志愿者的水平为0.70±0.10（标准误）。尽管样本量较小，但两组之间的差异具有统计学意义（P<0.001）。这些数据表明，t-PA释放缺陷可能导致镰状细胞贫血患者的高凝状态。
