Jordan J M, Allen N B, Pizzo S V
Am J Med. 1987 Mar;82(3):397-400. doi: 10.1016/0002-9343(87)90436-0.
The fibrinolytic system in a group of 23 patients with vasculitis and 10 patients with the cutaneous vasculitis atrophie blanche were studied. These patients were found to have markedly suppressed release of vascular tissue plasminogen activator (t-PA) stores whether the disease was active or in remission. The control group had releasable t-PA levels of 0.70 +/- 0.10 IU/ml of plasma. Levels of releasable t-PA in the patient population were 0.09 +/- 0.03 IU/ml for those with active vasculitis (p less than 0.0001 compared with the control group by the Student t test), 0.23 +/- 0.12 IU/ml for those with inactive vasculitis (p less than 0.001), and 0.03 +/- 0.01 IU/ml for those with atrophie blanche (p less than 0.0001). It is concluded that there is a generalized defect in plasminogen activator in a variety of vasculitides. Such a defect may contribute to the pathogenesis of lesions as well as the thromboembolic disease that may be observed in these patients.
对23例血管炎患者和10例患有白色萎缩性皮肤血管炎的患者的纤溶系统进行了研究。发现这些患者无论疾病处于活动期还是缓解期，血管组织纤溶酶原激活物（t-PA）储存的释放均明显受到抑制。对照组血浆中可释放的t-PA水平为0.70±0.10 IU/ml。活动期血管炎患者群体中可释放的t-PA水平为0.09±0.03 IU/ml（通过学生t检验，与对照组相比p<0.0001），非活动期血管炎患者为0.23±0.12 IU/ml（p<0.001），白色萎缩患者为0.03±0.01 IU/ml（p<0.0001）。结论是，在多种血管炎中存在纤溶酶原激活物的普遍缺陷。这种缺陷可能有助于病变的发病机制以及这些患者中可能观察到的血栓栓塞性疾病。
