Gazzaniga A B, Waxman K, Day A T, Bradford R R, Vanderhoof J A, Bivins B, Steiger E
Department of Surgery, University of California, Irvine 92717.
Arch Surg. 1988 Oct;123(10):1275-9. doi: 10.1001/archsurg.1988.01400340101018.
Normalization of plasma amino acid patterns and that relationship to improved nitrogen balance was studied using a pediatric-specific amino acid solution in 21 adults requiring total parenteral nutrition therapy. There was a significantly positive correlation between improved nitrogen balance and the amino acids cystine, tyrosine, total cysteine/cystine, and ornithine. When additional cysteine was added to the solution of 11 subjects, taurine also correlated with nitrogen balance. Despite higher amounts of histidine in solution, plasma amino acid levels were not normalized. These amino acids, heretofore considered nonessential, may be required in specific molar ratios in stress. The use of a 30% branched-chain pediatric-balanced amino acid solution resulted in near normalization of plasma amino acid levels and group mean positive nitrogen balance.
在21名需要全胃肠外营养治疗的成人中，使用儿科专用氨基酸溶液研究了血浆氨基酸模式的正常化及其与改善氮平衡的关系。改善的氮平衡与氨基酸胱氨酸、酪氨酸、总半胱氨酸/胱氨酸和鸟氨酸之间存在显著正相关。当向11名受试者的溶液中添加额外的半胱氨酸时，牛磺酸也与氮平衡相关。尽管溶液中组氨酸含量较高，但血浆氨基酸水平并未正常化。这些迄今为止被认为是非必需的氨基酸，在应激状态下可能需要特定的摩尔比。使用30%支链儿科平衡氨基酸溶液可使血浆氨基酸水平接近正常化，并使组平均氮平衡呈正。
