Thornton L, Griffin E
Coombe Lying-In Hospital, Dublin, Republic of Ireland.
Arch Dis Child. 1991 Jan;66(1 Spec No):21-5. doi: 10.1136/adc.66.1_spec_no.21.
Vaminolact, an amino acid solution containing taurine, was given to 15 sick newborn babies. They were compared with a group of 10 babies who received a solution that did not contain taurine (Vamin glucose). Efficacy and safety were evaluated by monitoring plasma amino acid patterns, growth patterns, nitrogen balance, and biochemical and haematological profiles. No serious abnormalities in amino acid concentrations were found. After an initial fall the taurine concentration recovered more rapidly in those receiving the taurine supplement, though this difference was not significant. Phenylalanine concentrations were within the reference range in the group receiving Vaminolact, and were significantly lower than in the group receiving Vamin glucose. Metabolic acidosis, which occurred in several subjects in each group, was not a serious problem. Liver function tests remained satisfactory. Nitrogen retention was greater among those receiving Vaminolact than in the control group. Vaminolact is a safe and effective amino acid solution for use in critically ill babies.
给15名患病新生儿输注了含有牛磺酸的氨基酸溶液Vaminolact。将他们与一组接受不含牛磺酸溶液（Vamin葡萄糖）的10名婴儿进行比较。通过监测血浆氨基酸模式、生长模式、氮平衡以及生化和血液学指标来评估疗效和安全性。未发现氨基酸浓度有严重异常。虽然差异不显著，但接受牛磺酸补充剂的婴儿，其牛磺酸浓度在最初下降后恢复得更快。接受Vaminolact组的苯丙氨酸浓度在参考范围内，且显著低于接受Vamin葡萄糖组。每组均有几名受试者出现代谢性酸中毒，但并非严重问题。肝功能检查结果仍令人满意。接受Vaminolact的婴儿氮潴留情况比对照组更好。Vaminolact是一种用于危重新生儿的安全有效的氨基酸溶液。
