Department of Pharmacy and Center for Integrated Protein Science, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 München, Germany.
Chem Commun (Camb). 2019 Aug 27;55(70):10392-10395. doi: 10.1039/c9cc04849a.
The preference of N,N-aryl, alkyl tertiary amides for cis conformations has been exploited through the use of tertiary squaramides as hairpin turn units that promote the folding of aromatic β-sheets. Head-to-head aromatic arrangements were shown to prevail in sufficiently long bent aromatic sequences.
通过使用叔噁唑啉作为发夹环单元，利用 N,N-芳基、烷基叔酰胺的顺式构象偏好来促进芳香β-折叠。在足够长的弯曲芳香序列中，头对头的芳香排列被证明占主导地位。
