白血病演进的机制：源自先天性综合征的启示。
Mechanisms of Leukemia Evolution: Lessons from a Congenital Syndrome.
机构信息
Division of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel.
Division of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel; Sackler Medical School, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.
出版信息
Cancer Cell. 2019 Aug 12;36(2):115-117. doi: 10.1016/j.ccell.2019.07.004.
Studies of the mechanisms of acute leukemia transformation from a preleukemic state in humans are hampered by the absence of clinical preleukemia syndromes. In this issue of Cancer Cell, Labuhn et al. provide a functional genomics view on the leukemic evolution from congenital preleukemia in children with Down syndrome.
人类从白血病前期状态向急性白血病转化的机制研究受到临床白血病前期综合征缺失的阻碍。在本期《癌细胞》杂志中，Labuhn 等人从功能基因组学角度揭示了唐氏综合征患儿先天性白血病前期向白血病的演进过程。
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