Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
UNLV Population Health & Health Equity Initiative, Las Vegas, NV, USA.
J Geriatr Psychiatry Neurol. 2020 May;33(3):135-143. doi: 10.1177/0891988719868305. Epub 2019 Aug 13.
Subjective memory complaints (SMCs) are associated with mild cognitive impairment and dementia but are understudied in African Americans (AAs). We compared SMC endorsement in white and AA participants and evaluated predictors of diagnostic progression.
Initial visit variables, including SMC and memory performance, were compared within a cognitively normal race-matched sample of white and AA participants ( = 912; 456) to assess the presence and predictors of SMC, the predictors of future diagnostic progression, and the change in memory performance over time.
More white (32.9%) than AA (24.3%) participants reported SMC ( < .01, ϕ = -.10). Subjective memory complaint was predicted by memory performance ( = -0.03, standard error [SE] = 0.013, odds ratio [OR] = .968, < .05) and race ( = -0.99, SE = 0.080, OR = .373, < .001). Subjective memory complaints and memory performance were associated with progression, χ (3, n = 912) = 102.37, < .001. African American race (-2.05 ± 0.24 SE) and SMC (-0.45 ± 0.21 SE) were associated with worse memory performance at baseline and over time, (3) = 13.54, < .01.
In contrast to previous research, our study found that SMC is associated with diagnostic progression and objective memory declines in both white and AA participants.
主观记忆抱怨（SMCs）与轻度认知障碍和痴呆有关，但在非裔美国人（AAs）中研究较少。我们比较了白人和 AA 参与者中 SMC 的认可情况，并评估了诊断进展的预测因素。
在认知正常的种族匹配的白人和 AA 参与者（= 912；456）样本中，比较了初始就诊变量，包括 SMC 和记忆表现，以评估 SMC 的存在和预测因素、未来诊断进展的预测因素以及随时间推移记忆表现的变化。
更多的白人（32.9%）而非 AA（24.3%）参与者报告了 SMC（<.01，φ=-.10）。主观记忆抱怨由记忆表现（=-0.03，标准误差[SE] = 0.013，优势比[OR] =.968，<.05）和种族（=-0.99，SE = 0.080，OR =.373，<.001）预测。主观记忆抱怨和记忆表现与进展有关，χ（3，n = 912）= 102.37，<.001。非裔美国人种族（-2.05 ± 0.24 SE）和 SMC（-0.45 ± 0.21 SE）与基线和随时间推移的记忆表现较差有关，（3）= 13.54，<.01。
与之前的研究相比，我们的研究发现 SMC 与白人和 AA 参与者的诊断进展和客观记忆下降有关。
