Kasper Elisabeth, Brueggen Katharina, Grothe Michel J, Bruno Davide, Pomara Nunzio, Unterauer Elisabeth, Duering Marco, Ewers Michael, Teipel Stefan, Buerger Katharina
Department of Psychosomatic Medicine, University of Rostock.
German Center for Neurodegenerative Diseases (DZNE)-Rostock/Greifswald.
Neuropsychology. 2016 Nov;30(8):906-914. doi: 10.1037/neu0000287. Epub 2016 May 16.
Delayed recall of the first words of a list-the primacy position-is thought to be particularly dependent on intact memory consolidation. Hippocampal volume has been suggested as the primary neuronal correlate of delayed primacy recall in cognitively normal elderly individuals. Here, we studied the association of hippocampal volume with primacy recall in individuals with amnestic mild cognitive impairment (aMCI).
We investigated serial position performance in 88 subjects with aMCI using a 16-word list (the California Verbal Learning Test [CVLT]). Primacy and recency performance were measured during learning and delayed recall. Hippocampal volumes were automatically determined from structural MRI scans. We conducted regression analyses with bilateral hippocampal volumes as predictors and serial position indices as outcomes.
After controlling for age, gender, and total intracranial volume, bilateral hippocampal volume was not associated with primacy recall either during learning or delayed recall. Primacy performance during learning was associated with the right inferior and middle temporal gyrus as well as the right inferior parietal cortex and supramerginal gyrus. During delayed recall, primacy performance was related to the bilateral supramarginal gyri.
Our findings suggest a reduced primacy effect in aMCI already during learning, contrasting previous findings in normal cognitive aging. This might indicate impaired encoding and consolidation processes at an early stage of episodic memory acquisition. Furthermore, our data indicate that hippocampal volume may not be a relevant determinant of residual primacy performance in the stage of aMCI, which may rather depend on temporal and parietal neocortical networks. (PsycINFO Database Record
列表中首个单词的延迟回忆——首位位置——被认为特别依赖于完整的记忆巩固。海马体积已被认为是认知正常的老年人延迟首位回忆的主要神经元相关因素。在此，我们研究了遗忘型轻度认知障碍（aMCI）患者海马体积与首位回忆之间的关联。
我们使用一个包含16个单词的列表（加利福尼亚言语学习测试[CVLT]）对88名aMCI患者的系列位置表现进行了研究。在学习和延迟回忆期间测量首位和近因表现。海马体积通过结构MRI扫描自动确定。我们以双侧海马体积作为预测变量，系列位置指数作为结果进行了回归分析。
在控制了年龄、性别和总颅内体积后，双侧海马体积在学习或延迟回忆期间均与首位回忆无关。学习期间的首位表现与右侧颞下回和颞中回以及右侧顶下小叶和缘上回相关。在延迟回忆期间，首位表现与双侧缘上回有关。
我们的研究结果表明，aMCI患者在学习期间就已经出现首位效应降低，这与正常认知老化的先前研究结果形成对比。这可能表明在情景记忆获取的早期阶段编码和巩固过程受损。此外，我们的数据表明，海马体积可能不是aMCI阶段剩余首位表现的相关决定因素，后者可能更多地依赖于颞叶和顶叶新皮质网络。（PsycINFO数据库记录）
