Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile.
Institut Químic de Sarrià (IQS), University Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain.
Nanomedicine (Lond). 2019 Aug;14(16):2243-2267. doi: 10.2217/nnm-2019-0052. Epub 2019 Aug 14.
Aging, exposure to oxidants, infectious pathogens, inflammogens, ultraviolet radiation and other environmental and genetic factors can result in the development of various skin disorders. Despite immense progress being made in dermatological treatments, many skin-associated problems still remain difficult to treat and various therapies have limitations. Progress in silica-based nanomaterials research provides an opportunity to overcome these drawbacks and improve therapies and is a promising tool for inclusion in clinical practice to treat skin diseases. This review focuses on the use of various types of silica nanoparticles with therapeutic applications in various skin disorders. These nanosystems improve treatment efficacy by maintaining or enhancing the effect of several drugs and are useful tools for nanomedicine, pharmaceutical sciences and future clinical applications.
衰老是、接触氧化剂、传染病病原体、促炎剂、紫外线辐射和其他环境和遗传因素会导致各种皮肤疾病的发展。尽管在皮肤病治疗方面取得了巨大进展，但许多与皮肤相关的问题仍然难以治疗，各种疗法都存在局限性。基于二氧化硅的纳米材料研究的进展为克服这些缺点和改进治疗方法提供了机会，是一种很有前途的工具，可以纳入临床实践中治疗皮肤疾病。这篇综述重点介绍了各种类型的二氧化硅纳米粒子在各种皮肤疾病中的治疗应用。这些纳米系统通过维持或增强几种药物的效果来提高治疗效果，是纳米医学、药物科学和未来临床应用的有用工具。
