School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China.
Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jan;13(1):e1658. doi: 10.1002/wnan.1658. Epub 2020 Jun 29.
As a consequence of recent progression in biomedicine and nanotechnology, nanomedicine has emerged rapidly as a new discipline with extensive application of nanomaterials in biology, medicine, and pharmacology. Among the various nanomaterials, silica nanoparticles (SNPs) are particularly promising in nanomedicine applications due to their large specific surface area, adjustable pore size, facile surface modification, and excellent biocompatibility. This paper reviews the synthesis of SNPs and their recent usage in drug delivery, biomedical imaging, photodynamic and photothermal therapy, and other applications. In addition, the possible adverse effects of SNPs in nanomedicine applications are reviewed from reported in vitro and in vivo studies. Finally, the potential opportunities and challenges for the future use of SNPs are discussed. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies.
由于生物医学和纳米技术的最新进展，纳米医学作为一个新的学科迅速崛起，纳米材料在生物学、医学和药理学中得到了广泛的应用。在各种纳米材料中，由于其具有较大的比表面积、可调节的孔径、易于表面修饰和优异的生物相容性，硅纳米颗粒（SNPs）在纳米医学应用中特别有前途。本文综述了 SNPs 的合成及其在药物传递、生物医学成像、光动力和光热治疗等方面的最新应用。此外，还从已报道的体外和体内研究中综述了 SNPs 在纳米医学应用中可能产生的不良反应。最后，讨论了 SNPs 未来应用的潜在机遇和挑战。本文属于以下分类： 生物技术中的纳米技术方法 > 生物学中的纳米级系统 治疗方法和药物发现 > 新兴技术。
