四价金属离子客体在多金属氧酸盐化学中的应用：[MOPd(PO)]（M = Sn，Pb）的合成与抗癌活性。
Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MOPd(PO)] (M = Sn, Pb).
机构信息
Department of Life Sciences and Chemistry , Jacobs University , Campus Ring 1 , 28759 Bremen , Germany.
Departament de Química Física i Inorgànica , Universitat Rovira i Virgili , c/Marcel·lí Domingo 1 , 43007 Tarragona , Spain.
出版信息
Inorg Chem. 2019 Sep 3;58(17):11294-11299. doi: 10.1021/acs.inorgchem.9b01129. Epub 2019 Aug 14.
The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MOPd(PO)] (M = Sn, Pb), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.
首例包含四价金属离子客体的多金属氧代钯酸盐(II)（POPs），[MOPd(PO)]（M = Sn，Pb），已经在固态、溶液和气相中被制备和结构表征。通过理论计算研究了金属离子客体与钯-氧壳之间的相互作用。POPs 通过诱导氧化应激引起半胱天冬酶激活和白血病细胞的连续凋亡，表现出抗癌活性。
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