有机金属抗癌药物干扰细胞能量过程：诱导癌细胞死亡的微妙方法。
Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death.
机构信息
Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland.
出版信息
Dalton Trans. 2013 Feb 21;42(7):2347-50. doi: 10.1039/c2dt31936e. Epub 2012 Dec 5.
PMID:23223548
Abstract
Two hybrid compounds comprising an antimetastatic ruthenium-arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.
摘要
已经制备了两种包含反转移金属钌-芳烃片段与抑制癌细胞有氧糖酵解的吲唑-3-羧酸衍生物连接的混合化合物，并在多种癌细胞系（包括高度相关的人胶质母细胞瘤细胞）中进行了评估，观察到两种成分之间存在明显的协同作用。
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