Department of Medical Science, University of Guanajuato, León, Mexico.
Mexican Institute of Social Security, León, Mexico.
Horm Res Paediatr. 2019;92(1):28-35. doi: 10.1159/000501718. Epub 2019 Aug 14.
The aim of this study was to evaluate soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) in adolescents with and without obesity (OB) and their correlation with vascular damage.
This is a cross-sectional study with 15-19 years old adolescents: 33 with OB and 33 with normal weight (NW), each group included 17 male and 16 female. Lipid profile, insulin, carboxymethylysine (CML), sRAGE, total AGEs, and dietary AGEs intake (dAGEs) were evaluated. Vascular damage was measured by flow-mediated vasodilation (FMD) and arterial stiffness index (Iβ). Homeostatic model assessment-insulin (HOMA-IR) and atherogenic index (AI) were calculated.
The group with OB had higher triglycerides (TG; p < 0.0001), AI (p < 0.001), HOMA-IR (p < 0.0001), dAGEs intake (p < 0.0001), lower CML (p = 0.05), total AGEs (p < 0.01), sRAGE (p < 0.001), and FMD (p < 0.002). In the total group, sRAGE correlated with AI (r = -0.26 p = 0.037); in the NW group, CML correlated with Iβ (r = -0.36; p = 0.037); and in the group of adolescents with OB, sRAGE correlated with FMD (r = -0.37; p = 0.037) and Iβ (r = 0.47; p = 0.006), while CML and total AGEs correlated with AI, p = 0.007 and p < 0.01, respectively).
The group of adolescents with OB showed higher cardiometabolic risk as shown by higher TG, AI, HOMA-IR, and lower sRAGE and FMD. sRAGE correlated negatively with FMD and positively with Iβ, so it could be suggested as a biochemical marker of impaired endothelial function.
本研究旨在评估肥胖（OB）和非肥胖（NW）青少年的可溶性晚期糖基化终产物受体（sRAGE）和晚期糖基化终产物（AGEs）及其与血管损伤的相关性。
这是一项横断面研究，纳入了 15-19 岁的青少年：33 名肥胖者和 33 名体重正常者，每组包括 17 名男性和 16 名女性。评估了血脂谱、胰岛素、羧甲基赖氨酸（CML）、sRAGE、总 AGEs 和饮食 AGEs 摄入量（dAGEs）。通过血流介导的血管舒张（FMD）和动脉僵硬度指数（Iβ）来测量血管损伤。计算了稳态模型评估的胰岛素抵抗指数（HOMA-IR）和致动脉粥样硬化指数（AI）。
OB 组的甘油三酯（TG；p < 0.0001）、AI（p < 0.001）、HOMA-IR（p < 0.0001）、dAGEs 摄入量（p < 0.0001）、CML（p = 0.05）、总 AGEs（p < 0.01）、sRAGE（p < 0.001）和 FMD（p < 0.002）水平均较高。在总人群中，sRAGE 与 AI 呈负相关（r = -0.26，p = 0.037）；在 NW 组中，CML 与 Iβ 呈负相关（r = -0.36，p = 0.037）；在 OB 组的青少年中，sRAGE 与 FMD（r = -0.37，p = 0.037）和 Iβ（r = 0.47，p = 0.006）呈负相关，而 CML 和总 AGEs 与 AI 呈正相关，p = 0.007 和 p < 0.01。
OB 组青少年的心血管代谢风险较高，表现为甘油三酯、AI、HOMA-IR 较高，sRAGE 和 FMD 较低。sRAGE 与 FMD 呈负相关，与 Iβ 呈正相关，因此可作为内皮功能受损的生化标志物。
