Flores-Ramírez Anaisa G, Ibarra-Reynoso Lorena Del R, Garay-Sevilla Ma Eugenia
Department of Medical Sciences, Division of Heath Sciences, Universidad de Guanajuato, Campus León, Guanajuato, Mexico.
Gac Med Mex. 2023;159(1):10-16. doi: 10.24875/GMM.M22000736.
Obesity has been shown to be associated with low levels of soluble receptor for advanced glycation end products (sRAGE).
To evaluate the levels of sRAGE and its association with the lipid index in children with obesity.
Cross-sectional study of children with obesity aged between six and 11 years. Anthropometric measurements, glucose, lipid profile, insulin and sRAGE were evaluated; body mass index, total cholesterol/high-density cholesterol (TC/HDL-C), triglycerides/glucose (TG/glucose), and triglycerides/HDL-C (TG-HDL-C) ratios and HOMA-IR were also calculated.
Eighty children were studied, among which 50% were males and 50% females. Females had higher values for waist circumference, HOMA-IR, and TG/HDL-C and TG/glucose ratios. No significant differences were found for sRAGE. When the variables were compared according to TG/HDL-C ratio tertiles, higher TC/HDL, TG/glucose, and sRAGE values were found at upper tertile. A significant correlation was observed between sRAGE and HOMA-IR (p < 0.03) in males, and between sRAGE and TG/HDL-C (p < 0.01) and TG/glucose ratios (p < 0.008) in females.
The female gender showed more cardiovascular risk factors and higher sRAGE at TG/HDL-C upper tertile. Further studies are required to test the possible predictive effect of higher risk for developing metabolic and cardiovascular complications.
肥胖已被证明与晚期糖基化终产物可溶性受体（sRAGE）水平低有关。
评估肥胖儿童中sRAGE的水平及其与血脂指数的关联。
对6至11岁的肥胖儿童进行横断面研究。评估人体测量指标、血糖、血脂谱、胰岛素和sRAGE；还计算了体重指数、总胆固醇/高密度胆固醇（TC/HDL-C）、甘油三酯/血糖（TG/葡萄糖）、甘油三酯/高密度脂蛋白胆固醇（TG-HDL-C）比值以及稳态模型评估的胰岛素抵抗（HOMA-IR）。
研究了80名儿童，其中50%为男性，50%为女性。女性的腰围、HOMA-IR、TG/HDL-C和TG/葡萄糖比值较高。sRAGE未发现显著差异。根据TG/HDL-C比值三分位数比较变量时，在最高三分位数处发现较高的TC/HDL、TG/葡萄糖和sRAGE值。男性中sRAGE与HOMA-IR之间存在显著相关性（p<0.03），女性中sRAGE与TG/HDL-C（p<0.01）和TG/葡萄糖比值（p<0.008）之间存在显著相关性。
女性在TG/HDL-C最高三分位数时表现出更多心血管危险因素和更高的sRAGE。需要进一步研究来测试代谢和心血管并发症高风险的可能预测作用。
