Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
Key laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China.
Int J Environ Res Public Health. 2019 Aug 13;16(16):2898. doi: 10.3390/ijerph16162898.
To investigate the relationship between low birthweight (LBW) and blood pressure and to assess whether LBW leads to a higher risk of high blood pressure (HBP) by gender in Chinese students aged 6-18 years. Also, to investigate whether the association was affected by childhood obesity.
Data was obtained from a baseline dataset of a national school-based program. Anthropometric parameters, including height, weight, and blood pressure, were measured, while birthweight and other characteristics were obtained from questionnaires. Stratified chi-squared tests were used to compare the prevalence of HBP between LBW and normal birthweight (NBW) groups in each age and sex category. Multivariable logistic regressions were conducted to estimate the HBP risks in each birthweight group.
Both systolic and diastolic blood pressure showed a U-shaped relationship with increased birthweight. Compared to NBW groups, LBW girls showed a higher HBP risk, with an odds ratio of 1.29 (95% confidence interval (CI): 1.02, 1.64, = 0.033), regardless of their current body mass index status, while no significant association in boys was found. : Low birthweight is associated with higher HBP risk in adolescent girls, regardless of their childhood BMI status.
研究低出生体重（LBW）与血压之间的关系，并评估在中国 6-18 岁学生中，LBW 是否会因性别而导致高血压（HBP）风险增加。此外，还评估了儿童肥胖是否会影响这种关联。
数据来自一项全国性学校为基础的项目的基线数据集。测量了身高、体重和血压等人体测量参数，同时从问卷中获取了出生体重和其他特征。在每个年龄和性别类别中，采用分层卡方检验比较 LBW 组和正常出生体重（NBW）组之间 HBP 的患病率。采用多变量逻辑回归估计每个出生体重组的 HBP 风险。
收缩压和舒张压均呈现出与出生体重增加的 U 型关系。与 NBW 组相比，LBW 女孩无论目前的体重指数状态如何，HBP 风险均较高，比值比为 1.29（95%置信区间（CI）：1.02，1.64， = 0.033），而男孩中则未发现显著关联。
低出生体重与青少年女孩的 HBP 风险增加有关，而与她们的儿童 BMI 状态无关。
