Kawai Junya, Mori Koichiro, Hirasawa Noriyasu
Mushroom Research Laboratory, Hokuto Corporation, Nagano, Japan.
Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
Biosci Biotechnol Biochem. 2019 Dec;83(12):2280-2287. doi: 10.1080/09168451.2019.1654360. Epub 2019 Aug 14.
The increasing number of patients suffering from allergic diseases is a global health problem. is an edible mushroom consumed as a health food in Asia, and has recently been reported to have anti-allergic effects. We previously reported that extract (GFE) and its active components, ergosterol and its derivatives, inhibited the antigen-induced activation of RBL-2H3 cells. Here, we demonstrated that GFE and ergosterol also had an inhibitory effect on the degranulation of bone marrow-derived mast cells (BMMCs) and alleviated anaphylactic cutaneous responses in mice. Using an air pouch-type allergic inflammation mouse model, we confirmed that oral administration of GFE and ergosterol suppressed the degranulation of mast cells . Our findings suggest that , including ergosterol as its active component, reduces type I allergic reactions by suppressing mast cell degranulation in mice, and might be a novel functional food that prevents allergic diseases.
过敏疾病患者数量的不断增加是一个全球性的健康问题。[某种蘑菇名称]是一种在亚洲作为健康食品食用的可食用蘑菇，最近有报道称其具有抗过敏作用。我们之前报道过[某种蘑菇名称]提取物（GFE）及其活性成分麦角固醇及其衍生物可抑制抗原诱导的RBL - 2H3细胞活化。在此，我们证明GFE和麦角固醇对骨髓来源的肥大细胞（BMMCs）的脱颗粒也有抑制作用，并减轻了小鼠的过敏性皮肤反应。使用气囊型过敏性炎症小鼠模型，我们证实口服GFE和麦角固醇可抑制肥大细胞的脱颗粒。我们的研究结果表明，以麦角固醇作为其活性成分的[某种蘑菇名称]通过抑制小鼠肥大细胞脱颗粒来减轻I型过敏反应，可能是一种预防过敏性疾病的新型功能性食品。
