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接受急诊手术的急性呼吸窘迫综合征患者或有急性呼吸窘迫综合征风险患者的围手术期麻醉管理。

Perioperative anaesthetic management of patients with or at risk of acute distress respiratory syndrome undergoing emergency surgery.

作者信息

Battaglini Denise, Robba Chiara, Rocco Patricia Rieken Macêdo, De Abreu Marcelo Gama, Pelosi Paolo, Ball Lorenzo

机构信息

Anaesthesia and Intensive Care, IRCCS for Oncology and Neurosciences, San Martino Policlinico Hospital, Genoa, Italy.

Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.

出版信息

BMC Anesthesiol. 2019 Aug 14;19(1):153. doi: 10.1186/s12871-019-0804-9.

Abstract

Patients undergoing emergency surgery may present with the acute respiratory distress syndrome (ARDS) or develop this syndrome postoperatively. The incidence of ARDS in the postoperative period is relatively low, but the impact of ARDS on patient outcomes and healthcare costs is relevant Aakre et.al (Mayo Clin Proc 89:181-9, 2014).The development of ARDS as a postoperative pulmonary complication (PPC) is associated with prolonged hospitalisation, longer duration of mechanical ventilation, increased intensive care unit length of stay and high morbidity and mortality Ball et.al (Curr Opin Crit Care 22:379-85, 2016). In order to mitigate the risk of ARDS after surgery, the anaesthetic management and protective mechanical ventilation strategies play an important role. In particular, a careful integration of general anaesthesia with neuraxial or locoregional techniques might promote faster recovery and reduce opioid consumption. In addition, the use of low tidal volume, minimising plateau pressure and titrating a low-moderate PEEP level based on the patient's need can improve outcome and reduce intraoperative adverse events. Moreover, perioperative management of ARDS patients includes specific anaesthesia and ventilator settings, hemodynamic monitoring, moderately restrictive fluid administration and pain control.The aim of this review is to provide an overview and evidence- and opinion-based recommendations concerning the management of patients at risk of and with ARDS who undergo emergency surgical procedures.

摘要

接受急诊手术的患者可能在术前就已出现急性呼吸窘迫综合征(ARDS),或在术后发展为该综合征。ARDS在术后阶段的发生率相对较低,但ARDS对患者预后和医疗成本的影响却不容忽视(Aakre等人,《梅奥临床学报》89:181 - 189,2014年)。ARDS作为术后肺部并发症(PPC)的发生与住院时间延长、机械通气时间延长、重症监护病房住院时间增加以及高发病率和死亡率相关(Ball等人,《当代危重病医学观点》22:379 - 385,2016年)。为降低术后发生ARDS的风险,麻醉管理和保护性机械通气策略起着重要作用。特别是,将全身麻醉与神经轴或局部区域技术仔细结合,可能会促进更快恢复并减少阿片类药物的使用。此外,采用低潮气量、将平台压降至最低并根据患者需求滴定低至中度的呼气末正压(PEEP)水平,可改善预后并减少术中不良事件。此外,ARDS患者的围手术期管理包括特定的麻醉和呼吸机设置、血流动力学监测、适度限制性液体管理和疼痛控制。本综述的目的是提供关于接受急诊手术的有ARDS风险患者和ARDS患者管理的概述以及基于证据和意见的建议。

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