Saitsu Yuusuke, Nishide Akemi, Kikushima Kenji, Shimizu Kuniyoshi, Ohnuki Koichiro
Department of Biological and Environmental Chemistry, Kindai University.
Radiation Effects Association.
Biomed Res. 2019;40(4):125-131. doi: 10.2220/biomedres.40.125.
Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by taking supplements containing fruiting body of H. erinaceus for 12 weeks. We performed three kinds of tests: Mini Mental State Examination (MMSE), Benton visual retention test, and Standard verbal paired-associate learning test (S-PA). MMSE alone showed that oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration. We speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects to the brain neural networks and improve cognitive functions. Oral intake of H.erinaceus is safe and convenient method for dementia prevention so far.
猴头菇自古以来就被视为药用菌，但它对人类健康的科学依据仍不明确。在本研究中，我们进行了一项随机、双盲、安慰剂对照的平行组比较研究，以评估服用含猴头菇子实体的补充剂12周对认知功能的改善情况。我们进行了三种测试：简易精神状态检查表（MMSE）、本顿视觉保持测验和标准言语配对联想学习测验（S-PA）。仅MMSE显示，口服猴头菇能显著改善认知功能并防止其恶化。我们推测，该蘑菇中的多种化合物，包括猴头菌素，对大脑神经网络有多种作用并能改善认知功能。到目前为止，口服猴头菇是预防痴呆症的安全便捷方法。
