Argoudelis A D, Baczynskyj L, Mizsak S A, Shilliday F B, Wiley P F
Upjohn Company, Kalamazoo, MI 49001.
J Antibiot (Tokyo). 1988 Sep;41(9):1212-22. doi: 10.7164/antibiotics.41.1212.
Senfolomycins A and B (Antimicrob. Agents Chemother.-1965: 828-831, 1966) are two antibacterial agents with physico-chemical and biological properties similar to those of paulomycin. Recent studies indicate that senfolomycin A (C29H36N2O16S, MW 700) has molecular composition and fast atom bombardment MS fragmentation pattern identical to those of paulomycin E. Extensive NMR work indicates that the two antibiotics, which have been separated by HPLC and TLC, differ only in the stereochemistry of the OCH3 group present in their respective sugar moieties. Indirect evident suggests that senfolomycin B is dihydrosenfolomycin A (C29H38N2O16S, MW 702) and in this respect it is related to paulomycin F. The proposed structures for senfolomycins A and B are discussed.
蛇麻霉素A和B（《抗菌剂与化疗》-1965年：828 - 831页，1966年）是两种抗菌剂，其物理化学性质和生物学性质与保洛霉素相似。最近的研究表明，蛇麻霉素A（C29H36N2O16S，分子量700）的分子组成和快原子轰击质谱裂解模式与保洛霉素E相同。广泛的核磁共振研究表明，通过高效液相色谱法和薄层色谱法分离得到的这两种抗生素，仅在各自糖部分中存在的OCH3基团的立体化学上有所不同。间接证据表明蛇麻霉素B是二氢蛇麻霉素A（C29H38N2O16S，分子量702），在这方面它与保洛霉素F有关。文中讨论了蛇麻霉素A和B的推测结构。
