保罗链霉菌产生的新型保罗霉素。
New paulomycins produced by Streptomyces paulus.
作者信息
Argoudelis A D, Baczynskyj L, Haak W J, Knoll W M, Mizsak S A, Shilliday F B
机构信息
Upjohn Company, Kalamazoo, Michigan 49001.
出版信息
J Antibiot (Tokyo). 1988 Feb;41(2):157-69. doi: 10.7164/antibiotics.41.157.
Paulomycin A2 (C34H46N2O17S), paulomycin C (C32H42N2O17S), paulomycin D (C31H40N2O17S), paulomycin E (C29H36N2O16S) and paulomycin F (C29H38N2O16S) have been isolated from fermentations of Streptomyces paulus strain 273. The structure of these compounds was determined using NMR and mass spectroscopic techniques. The new paulomycins, like paulomycins A and B (J. Antibiotics 35: 285-294, 1982) are highly active mainly against Gram-positive organisms.
保洛霉素A2（C34H46N2O17S）、保洛霉素C（C32H42N2O17S）、保洛霉素D（C31H40N2O17S）、保洛霉素E（C29H36N2O16S）和保洛霉素F（C29H38N2O16S）是从保罗链霉菌273菌株的发酵产物中分离得到的。这些化合物的结构通过核磁共振和质谱技术确定。与保洛霉素A和B（《抗生素杂志》35: 285 - 294, 1982）一样，这些新的保洛霉素主要对革兰氏阳性菌具有高度活性。
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