Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Org Lett. 2019 Sep 6;21(17):6643-6647. doi: 10.1021/acs.orglett.9b02183. Epub 2019 Aug 15.
An efficient iodide-catalyzed/hydrogen peroxide mediated sulfenylation and selenylation of unprotected uracil and its derivatives with simple thiols and diselenides was established. This coupling tolerates a broad variety of functional groups to provide diverse 5-sulfur/selenium-substituted uracil derivatives in good to excellent yields (up to 93%).
建立了一种高效的碘催化/过氧化氢介导的未保护尿嘧啶及其衍生物与简单硫醇和二硒醚的磺化和硒化反应。这种偶联反应能够容忍多种官能团，以良好至优秀的收率（高达 93%）提供多种 5-硫/硒取代的尿嘧啶衍生物。
