Department of Pediatrics, Biwako-Gakuen Medical and Welfare Center of Yasu, 978-2 Kitazakura, Yasu, 520-2321, Japan.
Department of Pediatrics, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, 520-2192, Japan.
Epilepsy Res. 2019 Oct;156:106185. doi: 10.1016/j.eplepsyres.2019.106185. Epub 2019 Aug 5.
The main elements of the microcircuits in the cerebral cortex are excitatory glutamatergic pyramidal cells and inhibitory γ-aminobutyric acid (GABA) interneurons. Hypofunction/degeneration of GABAergic interneurons has been hypothesized to be a key to the neural circuit dysfunction that underlies epileptogenesis and the development of recurrent spontaneous seizures. Using two experimental animal models of neuronal migration disorders, this review reports that the insults to the immature developing brain causes interneurons to fail to undergo normal processes such as production, migration, and organization. These results represent critical evidence that supports a link between interneuron dysfunction and epilepsy.
大脑皮层微电路的主要元素是兴奋性谷氨酸能锥体细胞和抑制性γ-氨基丁酸（GABA）中间神经元。据推测，GABA 能中间神经元功能低下/退化是导致神经回路功能障碍的关键，而神经回路功能障碍是癫痫发生和反复自发性癫痫发作的基础。本综述使用两种神经元迁移障碍的实验动物模型报告称，对发育中不成熟大脑的损伤会导致中间神经元无法正常进行产生、迁移和组织等过程。这些结果提供了关键证据，支持中间神经元功能障碍与癫痫之间存在关联。
