Happle R
Z Hautkr. 1979 May 15;54(10):426-9.
Long-term treatment of alopecia areata with dinitrochlorobenzene is effective. During the last two and a half years, 227 patients who suffered, in the majority of cases, from total or subtotal hair loss, were treated by this method. Unilateral application of DNCB induced unilateral regrowth of hair in 88% of these patients. Under continuous treatment of both sides of the head, this initial response was followed by complete regrowth of hair in 78%. The same result could be obtained by application of squaric acid dibutylester, another potent contact allergen. This indicates that the essential mechanism is contact allergy. Possibly, the regrowth of hair is due to the induction of local nonspecific immunosuppression.
用二硝基氯苯长期治疗斑秃是有效的。在过去两年半的时间里，227例大多患有全秃或斑秃的患者接受了这种治疗方法。对这些患者中的88%进行单侧二硝基氯苯治疗可诱导单侧毛发再生。在对头两侧进行持续治疗的情况下，78%的患者在这种初始反应后毛发完全再生。使用另一种强效接触性变应原二丁基酒石酸也可获得相同结果。这表明其基本机制是接触性过敏。毛发再生可能是由于局部非特异性免疫抑制的诱导。
