Urasiński I, Proniewska M, Schumacher K
Acta Haematol Pol. 1979 Apr-Jun;10(2):129-36.
Quantitative determinations of lymphocytas were done in the active period of the disease, immediately after treatment by the COAP schedule and during remission. In 6 patients the determinations were done several times during 20 weeks of maintenance treatment. It was found that independently of the stage of the disease the absolute lymphocyte count and the counts of B and T populations were low, while that of lymphocyte O population was raised. It was observed that the reduced count concerned all 4 subclasses of lymphocytes B, that is those with surface receptors for IgA, IgM, IgG and IgE immunoglobulins. In remission the values of lymphocytes and their T and B subpopulations increased, failing, however, to reach the normal values. This rise was more pronounced in the case of lymphocytes T. Lymphocyte depression in these patients is explained by the authors as due mainly to intensive cytostatic treatment.
在疾病活动期、采用COAP方案治疗后立即以及缓解期进行了淋巴细胞的定量测定。6例患者在维持治疗的20周内进行了多次测定。结果发现，无论疾病处于何种阶段，淋巴细胞绝对计数以及B和T细胞群计数均较低，而O淋巴细胞群计数升高。观察到淋巴细胞B的所有4个亚类计数均降低，即具有IgA、IgM、IgG和IgE免疫球蛋白表面受体的亚类。缓解期淋巴细胞及其T和B亚群的值有所增加，但未达到正常值。T淋巴细胞的这种升高更为明显。作者认为这些患者的淋巴细胞减少主要是由于强化的细胞抑制治疗所致。
