Bensa J C, Micouin C, Schaerer R, Sotto J J, Hollard D
Biomedicine. 1977 Apr;26(2):137-44.
Peripheral blood lymphocytes forming E rosettes in the presence of sheep red blood cells and those bearing surface immunoglobulins (SIg) have been studied quantitatively as an evaluation of T and B lymphocytes in Hodgkin's disease. 62 patients were investigated, 21 of whom before any treatment. It appears that the lymphocytes forming E rosettes are significantly lower in percentage in 86% of the patients and in absolute count in 65%. SIg bearing lymphocytes are elevated in percentile in 61% of the cases, but the absolute count is normal in 50% of the patients and elevated in 30% only. At diagnosis the T/B lymphocytes equilibrium is modified in 13 among 21 patients but, after the initial treatment of the disease, the ratio is modified in 90% of the patients in complete remission and remains unchanged for years even in the absence of relapse or immnunosuppressive treatment. It is suggested that SIg + lymphocytes from the peripheral blood are actually B lymphocytes and not anti-T-antibody coated T lymphocytes or antigen-antibody lacking of membrane markers, which are numerous in one third of the investigated patients, might be T lymphocytes with qualitative abnormality.
在外周血淋巴细胞与绵羊红细胞形成E花环以及带有表面免疫球蛋白（SIg）的情况下，对其进行了定量研究，以此评估霍奇金病中的T淋巴细胞和B淋巴细胞。共研究了62例患者，其中21例在未接受任何治疗之前进行了检测。结果显示，86%的患者中形成E花环的淋巴细胞百分比显著降低，65%的患者其绝对计数降低。61%的病例中带有SIg的淋巴细胞百分位数升高，但50%的患者其绝对计数正常，仅30%的患者升高。在诊断时，21例患者中有13例T/B淋巴细胞平衡发生改变，但在疾病初始治疗后，完全缓解的患者中有90%的患者该比例发生改变，即使在无复发或免疫抑制治疗的情况下，该比例多年保持不变。有人提出，外周血中SIg+淋巴细胞实际上是B淋巴细胞，而非抗T抗体包被的T淋巴细胞，并且在三分之一的研究患者中大量存在的缺乏膜标记物的抗原抗体可能是具有定性异常的T淋巴细胞。
