Laskay T, Hansson M, Porwit A, Björkholm M, Berthold W, Kiessling R
Department of Immunology, Karolinska Institutet, Stockholm, Sweden.
J Biol Regul Homeost Agents. 1987 Jan-Mar;1(1):37-44.
Peripheral blood mononuclear cells (PBMC) from patients with aplastic anemia (AA) and healthy donors were compared with regard to their ability to produce soluble factors with inhibitory activity on in vitro granulopoiesis (GM-CFC). Although PBMC from AA patients produced enhanced levels of IFN-gamma as compared to controls, this lymphokine was found not to be the main inhibitor of in vitro granulopoiesis. Other, non-IFN related factors were potent inhibitors of both the mature and the immature precursors for GM-CFC, could act across the species barrier and were of low molecular weight. Also PBMC from healthy donors produced a non-IFN mediated GM-CFC inhibitory factor, but to a lesser degree and acting only on one type of myeloid precursors. The possible implications of these findings in relation to the etiology of AA will be discussed.
对再生障碍性贫血（AA）患者和健康供体的外周血单个核细胞（PBMC）产生对体外粒细胞生成（GM-CFC）具有抑制活性的可溶性因子的能力进行了比较。尽管与对照组相比，AA患者的PBMC产生的IFN-γ水平有所升高，但发现这种淋巴因子不是体外粒细胞生成的主要抑制剂。其他与IFN无关的因子是GM-CFC成熟和未成熟前体的有效抑制剂，可跨越种属屏障且分子量较低。健康供体的PBMC也产生一种非IFN介导的GM-CFC抑制因子，但程度较轻且仅作用于一种髓系前体。将讨论这些发现与AA病因相关的可能意义。
