Zou Cuihua, Wang Jie, Huang Xiaohua, Jian Chongdong, Zou Donghua, Li Xuebin
Department of Neurology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, People's Republic of China.
Department of Nephrology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, People's Republic of China.
Aging (Albany NY). 2019 Aug 16;11(16):6109-6119. doi: 10.18632/aging.102169.
Alzheimer's disease (AD) is a progressive neurodegenerative disease that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified and used to construct protein-protein interaction (PPI) networks. The AD-related PPI network was used to identify functional modules, and enrichment analysis showed that they were significantly involved in "Alzheimer's disease", "apoptosis", and related pathways. We predicted non-coding RNAs and transcription factors that may regulate the functional modules. The expression of hub genes and transcription factors was validated in an independent data set. The results in this study provide several candidates for further research on mechanisms of AD pathogenesis.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，在发达国家是第四大常见死因。在我们的研究中，鉴定了AD患者与健康个体之间差异表达的基因，并用于构建蛋白质-蛋白质相互作用（PPI）网络。利用AD相关的PPI网络来识别功能模块，富集分析表明它们显著参与了“阿尔茨海默病”、“细胞凋亡”及相关途径。我们预测了可能调节这些功能模块的非编码RNA和转录因子。在一个独立数据集中验证了枢纽基因和转录因子的表达。本研究结果为AD发病机制的进一步研究提供了几个候选对象。
